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Direct asymmetric aldol reaction of acetophenones with aromatic aldehydes catalyzed by chiral Al/Zn heterobimetallic compounds

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Abstract

Chiral Al/Zn heterobimetallic complexes are effective catalysts for the direct highly enantioselective aldol reaction of acetophenones with aromatic aldehydes. The Al site in the complex acts as a Lewis acid to activate aldehyde, whereas ethylzinc alkoxide plays a role of a Brønsted base to form a reactive zinc enolate with acetophenone. Distinct nature of two different metals contributes to the efficient direct asymmetric aldol reaction.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Yu Lin University, Yu Lin, Shaanxi, 719000, China

    Xiao Li, Xiaoju Liu, Xiangrong Ma & Yajun Ma

  2. Institute of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China

    Xiao Li, Lei Zhang, Yu-Hua Xiao, Qi-Peng Guo, Chao-Shan Da & Hong Li

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  1. Xiao Li
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Correspondence to Xiao Li.

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Li, X., Zhang, L., Xiao, YH. et al. Direct asymmetric aldol reaction of acetophenones with aromatic aldehydes catalyzed by chiral Al/Zn heterobimetallic compounds. Russ J Gen Chem 86, 1922–1930 (2016). https://doi.org/10.1134/S1070363216080247

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  • DOI: https://doi.org/10.1134/S1070363216080247

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