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Synthesis of tetrahydroisoquinoline derivatives and evaluation of their anti-breast cancer activity

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Abstract

Four novel tetrahydroisoquinoline derivatives 1–4 were synthesized and characterized by IR, 1H NMR, HRMS, and single crystal X-ray crystallography. Anticancer effect of the products were studied on five human breast cancer cell lines including MDA-MB-231, MDA-MB-468, SK-BR-3, MCF7, HCC70 T4-2. Compounds 3 and 4 demonstrated higher activity than 1 and 2.

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Authors and Affiliations

  1. Department of Breast Tumor Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China

    X. P. Zhang, X. W. Ding, X. M. He & D. H. Zou

  2. Department of Medical Record Management, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China

    F. J. Yu

Authors
  1. X. P. Zhang
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  2. F. J. Yu
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  3. X. W. Ding
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  4. X. M. He
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  5. D. H. Zou
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Corresponding author

Correspondence to D. H. Zou.

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The text was submitted by the authors in English.

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Zhang, X.P., Yu, F.J., Ding, X.W. et al. Synthesis of tetrahydroisoquinoline derivatives and evaluation of their anti-breast cancer activity. Russ J Gen Chem 86, 1430–1433 (2016). https://doi.org/10.1134/S1070363216060311

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  • DOI: https://doi.org/10.1134/S1070363216060311

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