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Synthesis, spectroscopic, and antimicrobial study of Ca(II), Fe(III), Pd(II), and Au(III) complexes of amoxicillin antibiotic drug

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Abstract

Synthesis, spectroscopic characterization, theoretical and antimicrobial studies of Ca(II), Fe(III), Pd(II), and Au(III) complexes of amoxicillin (amox) antibiotic drug are presented in the current paper. Structure of 1: 1 (metal: amox) complexes were elucidated on the basis of elemental analyses, and IR, Raman, 1H NMR, and electronic spectral data. According to molar conductance measurements the complexes had electrolyte nature. Amoxicillin reacted with metal ions as a tridentate ligand coordinated with metal ions via–NH2,–NH, and β-lactam carbonyl groups. The complexes were formulated as [Ca(amox-Na)(H2O)]·Cl2·4H2O (1), [Fe(amox-Na)(H2O)3]·Cl3·3H2O (2), [Pd(amox-Na)(H2O)]·Cl2 (3), and [Au(amox-Na)(H2O)]·Cl3 (4). Kinetic thermodynamic parameters (E*, ΔS*, ΔH*, and ΔG*) were calculated based on the Coats–Redfern and Horowitz–Metzger methods using thermo gravimetric curves of TG and DTG. Nanosize particles of amoxicillin complexes have been studied by XRD, SEM, and TEM methods. Theoretical studies of the synthesized complexes have been performed.

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Authors and Affiliations

  1. Department of Chemistry, College of Science, Princess Nora Bint Abdul Rahman University, Riyadh, Saudi Arabia

    F. A. I. Al-Khodir

  2. Deanship of Scientific Research, Princess Nora Bint Adul Rahman University, Riyadh, Saudi Arabia

    F. A. I. Al-Khodir

  3. Department of Chemistry, Faculty of Science, Port Said, Port Said University, Cairo, Egypt

    M. S. Refat

  4. Department of Chemistry, Faculty of Sciences, Taif University, Al-Haweiah, P.O. Box 888, Taif, 21974, Saudi Arabia

    M. S. Refat

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  1. F. A. I. Al-Khodir
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Al-Khodir, F.A.I., Refat, M.S. Synthesis, spectroscopic, and antimicrobial study of Ca(II), Fe(III), Pd(II), and Au(III) complexes of amoxicillin antibiotic drug. Russ J Gen Chem 86, 708–717 (2016). https://doi.org/10.1134/S1070363216030324

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