Abstract
A combined method of spectroscopic analysis of biochemical and structural markers of tumor changes, including blood volume, hemoglobin oxygen saturation, protoporphyrin IX accumulation, and change in the scattering properties, was developed on the basis of the results of simulation modeling of light propagation in media with optical properties similar to those of biotissues. The method was verified on a series of optical phantoms and applied in a clinical setting for intraoperative navigation with the aim of demarcation of glioblastoma multiforme borders. It was shown that the method developed is superior in sensitivity and specificity to the method of video-fluorescent visualization with a Carl Zeiss OPMI Pentero microscope and can be used for demarcation of the borders of tumors exhibiting infiltrative growth.
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Original Russian Text © T.A. Savelieva, V.B. Loshchenov, S.A. Goryainov, L.V. Shishkina, A.A. Potapov, 2013, published in Rossiiskii Khimicheskii Zhurnal, 2013, Vol. 57, No. 5, pp. 39–47.
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Savelieva, T.A., Loshchenov, V.B., Goryainov, S.A. et al. A spectroscopic method for simultaneous determination of protoporphyrin IX and hemoglobin in the nerve tissues at intraoperative diagnosis. Russ J Gen Chem 85, 1549–1557 (2015). https://doi.org/10.1134/S1070363215060341
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DOI: https://doi.org/10.1134/S1070363215060341