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First Polynuclear Palladium Compounds [(C5H12NO)(PdCl3)]n and [(C10H16NO)2(Pd2Cl6)] with High Antitumor and Radioprotective Activity

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Abstract

Polymeric palladium complexes [(C5H12NO)(PdCl3)]n (I) and [(C10H16NO)2(Pd2Cl6)] (II) were synthesized for the first time and studied by X-ray diffraction. Complexes I and II were found to have moderate toxicity (3rd class of toxicity) and high antitumor and radioprotective activities. Treatment of Lewis lung carcinoma (LLC) with I and II induced statistically significant antitumor and antimetastatic effects exceeding those of cisplatin: the use of I and II retarded the growth of LLC by 60.0%, while cisplatin retarded it by 48.0%. The decrease in the LLC metastasis was 75% upon the action of I, 91.0% in the case of II, and 69.0% for cisplatin. It was shown that II has a clear-cut radioprotective action. On single exposure of mice to a dose of 8.2 Gy, their survival rate was 58.0% versus 4.5% for the control. Fractional exposure to increasing doses (2.5, 3, and 3.5 Gy) resulted in 75.0% survival rate versus 33.0% for the control.

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ACKNOWLEDGMENTS

The X-ray diffraction study of compound I was performed using equipment of the Center for Collective Use, Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, within the state assignment. The X-ray diffraction data for II were collected at the Department of Chemistry, Durham University (UK).

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Authors and Affiliations

  1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    I. A. Efimenko, A. V. Churakov, N. A. Ivanova & O. S. Erofeeva

  2. Tsyb National Medical Research Radiological Center, Ministry of Health of the Russian Federation, 249031, Obninsk, Russia

    M. V. Filimonova, A. S. Samsonova, T. S. Podosinnikova & A. S. Filimonov

Authors
  1. I. A. Efimenko
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  2. M. V. Filimonova
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  3. A. V. Churakov
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  4. N. A. Ivanova
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  5. O. S. Erofeeva
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  6. A. S. Samsonova
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  7. T. S. Podosinnikova
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  8. A. S. Filimonov
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Correspondence to I. A. Efimenko.

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Translated by Z. Svitanko

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Efimenko, I.A., Filimonova, M.V., Churakov, A.V. et al. First Polynuclear Palladium Compounds [(C5H12NO)(PdCl3)]n and [(C10H16NO)2(Pd2Cl6)] with High Antitumor and Radioprotective Activity. Russ J Coord Chem 46, 339–349 (2020). https://doi.org/10.1134/S1070328420040028

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  • DOI: https://doi.org/10.1134/S1070328420040028

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