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Design, Synthesis, and Anti-Breast Cancer Activity of Some Hybrid Molecules Containing Coumarin Moiety

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Abstract

(Benzimidazol-2-yl)-7-hydroxycoumarin and N-(2-hydroxyphenyl)-7-hydroxycoumarin-3-carboxamide have been synthesized by the condensation of ethyl 7-hydroxycoumarin-3-carboxylate in acetic acid. Acetylation with acetic anhydride and halogenation with bromine in acetic acid’s presence of the previous compounds has yielded the corresponding acetoxy and dibromo derivatives. The synthesized molecules that contain coumarin ring have been evaluated for their activities against breast cancer and they have shown good in vitro antiproliferative activities against a human breast cancer line (MCF-7). The results have shown that 3-(benzimidazol-2-yl)-7-acetoxycoumarin had a significant cytotoxic effect compared to the standard DOX (doxorubicin) drug.

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ACKNOWLEDGMENTS

The authors are thankful to nuclear magnetic resonance lab in faculty of pharmacy, Mansoura University and nuclear magnetic resonance lab in Beni-suef University for using their laboratory equipments during.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Port-Said University, 42521, Port-Said, Egypt

    Eman M. Radwan, Elsherbiny H. Elsayed, Mohamed Abd El-Moneim & Amal M. Youssef Moustafa

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  1. Eman M. Radwan
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  2. Elsherbiny H. Elsayed
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  3. Mohamed Abd El-Moneim
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  4. Amal M. Youssef Moustafa
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Correspondence to Eman M. Radwan.

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Eman M. Radwan, Elsayed, E.H., El-Moneim, M.A. et al. Design, Synthesis, and Anti-Breast Cancer Activity of Some Hybrid Molecules Containing Coumarin Moiety. Russ J Bioorg Chem 47, 149–157 (2021). https://doi.org/10.1134/S1068162021010180

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