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O-Specific Polysaccharides (O-Antigens) of a New Species of Enteric Bacteria Escherichia albertii Closely Related to Escherichia coli

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Abstract—

The data on the structure of O-specific polysaccharides (O-antigens) of all nine known molecular types (potential O-serotypes) of a new type of enterobacteria Escherichia albertii, causative agents of intestinal infections in humans and birds, are presented. The advantages and limitations of structural analysis methods used to determine the structure of E. albertii polysaccharides are discussed. The annotation of genes in gene clusters of biosynthesis of O-antigens of E. albertii was carried out by comparison with the sequences in the available databases. Structural and genetic relationships between O-antigens of E. albertii and closely related species of E. coli are discussed. It was found that, in addition to the O-antigen, E. albertii O9 expresses a mannan of the same structure as the mannan of E. coli O8.

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ACKNOWLEDGMENTS

The authors express their gratitude to the colleagues from China H. Zheng, Y. Xiong, and J. Wang (National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China), and to H. Wang and Q. Li (Zigong Center for Disease Control and Prevention, Zigong, Sichuan Province, China) for their contribution in the genetic study of the O-antigens of E. albertii.

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Authors and Affiliations

  1. N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    O. I. Naumenko, S. N. Senchenkova & Yu. A. Knirel

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  1. O. I. Naumenko
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  2. S. N. Senchenkova
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  3. Yu. A. Knirel
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Correspondence to Yu. A. Knirel.

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Translated by E. Puchkov

Abbreviations: GCO, gene cluster of the O-antigen; OSP, O‑specific polysaccharide; CMP, cytidine monophosphate; Col, colitose (3,6-dideoxy-L-xylohexose); dTDP, deoxythymidine diphosphate; COSY, correlation spectroscopy; Fuc, fucose; GDP, guanidine diphosphate; GlcNAm3NAcA, 3-acetamido-2-acetymidoylamino-2,3-dideoxy-glucuronic acid; HMVC, heteronuclear multiple-bond correlation; HSQC, heteronuclear single-core coherence; ManNAc3NAcA, 2,3-diacetamido-2,3-dideoxymannanuronic acid; Neu5Ac, N-acetylneuraminic acid; NOESY, nuclear Overhauser effect spectroscopy; orf, open reading frame; P, phosphate; QuiNAc, N‑acetylquinosamine (2-acetamido-2,6-dideoxyglucose); Rha, rhamnose; RhaNAc, N-acetyl-L-rhamnosamine (2-acetamido-2,6-dideoxy oximannose); ROESY, rotating-frame nuclear Overhauser effect spectroscopy; UDP, uridine diphosphate; UndPP, undecaprenyl diphosphate; TOCSY, total correlation spectroscopy.

Corresponding author: phone: +7 (499) 137-61-48; e-mail: yknirel@gmail.com.

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Naumenko, O.I., Senchenkova, S.N. & Knirel, Y.A. O-Specific Polysaccharides (O-Antigens) of a New Species of Enteric Bacteria Escherichia albertii Closely Related to Escherichia coli. Russ J Bioorg Chem 45, 451–462 (2019). https://doi.org/10.1134/S1068162019060293

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