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Application of Natural Polysaccharides in Pharmaceutics

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Abstract

Modern data are presented on the pharmaceutical application of natural polysaccharides, such as pullulan, alginates, hyaluronic acid, dextrans, pectin, chitosan, and arabinogalactan, which are already actively used or can be used in the future for optimizing different drug forms, water solubility and improving bioavailability. The emphasis on natural polysaccharides is made in relation to their good biocompatibility, biodegradation, hydrophilicity, good stability, safety, lack of toxicity, and adhesive properties. The indicated parameters are important and necessary for agents used for drug delivery into the human body.

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Authors and Affiliations

  1. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    M. V. Khvostov, T. G. Tolstikova & S. A. Borisov

  2. Novosibirsk State University, 630090, Novosibirsk, Russia

    M. V. Khvostov & T. G. Tolstikova

  3. Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, 630128, Novosibirsk, Russia

    T. G. Tolstikova & A. V. Dushkin

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  2. T. G. Tolstikova
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  3. S. A. Borisov
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  4. A. V. Dushkin
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Correspondence to M. V. Khvostov.

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Translated by D. Novikova

Abbreviations: AG, arabinogalactan; ALG, alginates; AUC, area under pharmacokinetic curve; DEX, dextran; GLA, hyaluronic acid; KB, cell line derived from human cervical carcinoma cells; MCF7, cell line derived from invasive adenocarcinoma of human breast ducts; MDCK, Maidin-Darby canine kidney cells; PUL, pullulan; TEER, transepithelial electrical resistance; NSAIDs, non-steroidal anti-inflammatory drugs.

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Khvostov, M.V., Tolstikova, T.G., Borisov, S.A. et al. Application of Natural Polysaccharides in Pharmaceutics. Russ J Bioorg Chem 45, 438–450 (2019). https://doi.org/10.1134/S1068162019060219

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