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Plant Pathogenesis-Related Proteins Binding Lipids and Other Hydrophobic Ligands

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Abstract

Synthesis of defensive pathogenesis-related (PR) proteins in plants is induced by biotic and abiotic stress. The family of plant PR proteins is divided into 17 classes differing in their structural and functional properties. Two representative classes of plant PR protein family are Bet v 1 (PR-10) homologs and lipid transfer proteins (LTP, PR-14). The ability of PR-10 and PR-14 to bind and transfer lipids and other hydrophobic ligands contributes to a wide range of plant metabolic processes. Although these proteins are not homologous, they have similar spatial structures containing a hydrophobic cavity, which is capable of accommodating and retaining various molecules, including lipids. The present review focuses on structural features of Bet v 1 homologs and LTP, possible ways of binding and transfer of lipids, and assumed biological functions associated with the delivery of building and signaling hydrophobic molecules in plants, as well as participation of these proteins and their lipid ligands in the development of allergic reactions.

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Abbreviations

ASIT:

allergen-specific immunotherapy

FA:

fatty acids

GPI:

glycosylphosphatidylinositol

JA:

jasmonic acid

LTP:

lipid transfer protein

MHC:

major histocompatibility complex

PR proteins:

pathogenesis-related proteins

ROS:

reactive oxygen species

SA:

salicylic acid

References

  1. Palacin, A., Varela, J., Quirce, S., del Pozo, V., Tordesillas, L., Barranco, P., Fernandez-Nieto, M., Sastre, J., Diaz-Perales, A., and Salcedo, G., Clin. Exp. Allergy, 2009, vol. 39, pp. 1267–1276.

    Article  CAS  PubMed  Google Scholar 

  2. Bogdanov, I.V., Shenkarev, Z.O., Finkina, E.I., Melnikova, D.N., Rumynskiy, E.I., Arseniev, A.S., and Ovchinnikova, T.V., BMC Plant Biol., 2016, vol. 16, p. 1186. doi 10.1186/s12870-016-0792-6

    Article  CAS  Google Scholar 

  3. Samuel, D., Liu, Y.-J., Cheng, C.-S., and Lyu, P.-C., J. Biol. Chem., 2002, vol. 277, pp. 35267–35273.

    Article  CAS  PubMed  Google Scholar 

  4. Finkina, E.I., Melnikova, D.N., Bogdanov, I.V., and Ovchinnikova, T.V., Acta Naturae, 2016, vol. 8, pp. 47–61.

    Article  CAS  Google Scholar 

  5. Fernandes, H., Michalska, K., Sikorski, M., and Jaskolski, M., FEBS J., 2013, vol. 280, pp. 1169–1199.

    Article  CAS  PubMed  Google Scholar 

  6. Radauer, C., Lackner, P., and Breiteneder, H., BMC Evol. Biol., 2008, vol. 8, p. 1186.

    Article  CAS  Google Scholar 

  7. Yeats, T.H. and Rose, J.K.C., Protein Sci., 2008, vol. 17, pp. 191–198.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Charvolin, D., Douliez, J.P., Marion, D., Cohen-Addad, C., and Pebay-Peyroula, E., Eur. J. Biochem., 1999, vol. 264, pp. 562–568.

    Article  CAS  PubMed  Google Scholar 

  9. Caille, A., Douliez, J., and Marion, D., Eur. J. Biochem., 2000, vol. 1124, pp. 1117–1124.

    Google Scholar 

  10. Regent, M.C., Giudici, A.M., Villalaín, J., and de la Canal, L., Lett. Appl. Microbiol., 2005, vol. 40, pp. 183–189.

    Article  CAS  Google Scholar 

  11. Cheng, C.S., Chen, M.N., Lai, Y.T., Chen, T., Lin, K.F., Liu, Y.J., and Lyu, P.C., Proteins Struct. Funct. Genet., 2008, vol. 70, pp. 695–706.

    Article  CAS  PubMed  Google Scholar 

  12. Lerche, M.H. and Poulsen, F.M., Protein Sci., 1998, vol. 7, pp. 2490–2498.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Diz, M.S., Carvalho, A.O., Ribeiro, S.F.F., Da Cunha, M., Beltramini, L., Rodrigues, R., Nascimento, V.V., Machado, O.L.T., and Gomes, V.M., Physiol. Plant., 2011, vol. 142, pp. 233–246.

    Article  CAS  PubMed  Google Scholar 

  14. Melnikova, D.N., Shenkarev, Z.O., Finkina, E.I., Sukhanov, S.V., Boldyrev, I.A., Gizatullina, A.K., Mineev, K.S., Arseniev, A.S., and Ovchinnikova, T.V., Biochemistry, 2017, vol. 56, pp. 1785–1796.

    Article  CAS  PubMed  Google Scholar 

  15. Edqvist, J., Blomqvist, K., Nieuwland, J., and Salminen, T.A., J. Lipid Res., 2018. doi 10.1194/jlr.R083139

    Google Scholar 

  16. Sodano, P., Caille, A., Sy, D., De Person, G., Marion, D., and Ptak, M., FEBS Lett., 1997, vol. 416, pp. 130–134.

    Article  CAS  PubMed  Google Scholar 

  17. Petit, M.C., Sodano, P., Marion, D., and Ptak, M., Eur. J. Biochem., 1994, vol. 222, pp. 1047–1054.

    Article  CAS  PubMed  Google Scholar 

  18. Douliez, J.-P., Michon, T., Elmorjani, K., and Marion, D., J. Cereal Sci., 2000, vol. 32, pp. 1–20.

    Article  CAS  Google Scholar 

  19. Pato, C., Le Borgne, M., Le Baut, G., Le Pape, P., Marion, D., and Douliez, J.-P., Biochem. Pharmacol., 2001, vol. 62, pp. 555–560.

    Article  CAS  PubMed  Google Scholar 

  20. Bakan, B., Hamberg, M., Larue, V., Prang, T., Marion, D., and Lascombe, M.B., Biochem. Biophys. Res. Commun., 2009, vol. 390, pp. 780–785.

    Article  CAS  PubMed  Google Scholar 

  21. Bakan, B., Hamberg, M., Perrocheau, L., Maume, D., Rogniaux, H., Tranquet, O., Rondeau, C., Blein, J.-P., Ponchet, M., and Marion, D., J. Biol. Chem., 2006, vol. 281, pp. 38981–38988.

    Article  CAS  PubMed  Google Scholar 

  22. Cubells-Baeza, N., Gómez-Casado, C., Tordesillas, L., Ramírez-Castillejo, C., Garrido-Arandia, M., González-Melendi, P., Herrero, M., Pacios, L.F., and Díaz-Perales, A., Plant. Mol. Biol., 2017, vol. 94, pp. 33–44.

    Article  CAS  PubMed  Google Scholar 

  23. Guerbette, F., Grosbois, M., Jolliot-Croquin, A., Kader, J.C., and Zachowski, A., Biochemistry, 1999, vol. 38, pp. 14131–14137.

    Article  CAS  PubMed  Google Scholar 

  24. Guerbette, F., Grosbois, M., Jolliot-Croquin, A., Kader, J.C., and Zachowski, A., Mol. Cell. Biochem., 1999, vol. 192, pp. 157–161.

    Article  CAS  PubMed  Google Scholar 

  25. Douliez, J.P., Jégou, S., Pato, C., Mollé, D., Tran, V., and Marion, D., Eur. J. Biochem., 2001, vol. 268, pp. 384–388.

    Article  CAS  PubMed  Google Scholar 

  26. Caaveiro, J.M.M., Molina, A., González-Mañas, J.M., Rodríguez-Palenzuela, P., García-Olmedo, F., and Goñi, F.M., FEBS Lett., 1997, vol. 410, pp. 338–342.

    Article  CAS  PubMed  Google Scholar 

  27. Śliwiak, J., Dauter, Z., and Jaskolski, M., Biotechnologia, 2013, vol. 1, pp. 47–50.

    Article  Google Scholar 

  28. Neudecker, P., Schweimer, K., Nerkamp, J., Scheurer, S., Vieths, S., Sticht, H., and Rösch, P., J. Biol. Chem., 2001, vol. 276, pp. 22756–22763.

    Article  CAS  PubMed  Google Scholar 

  29. Mogensen, J.E., Wimmer, R., Larsen, J.N., Spangfort, M.D., and Otzen, D.E., J. Biol. Chem., 2002, vol. 277, pp. 23684–23692.

    Article  CAS  PubMed  Google Scholar 

  30. Zubini, P., Zambelli, B., Musiani, F., Ciurli, S., Bertolini, P., and Baraldi, E., Plant Physiol., 2009, vol. 150, pp. 1235–1247.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Mattila, K. and Renkonen, R., Scand. J. Immunol., 2009, vol. 70, pp. 116–124.

    Article  CAS  PubMed  Google Scholar 

  32. Seutter von Loetzen, C., Hoffmann, T., Hartl, M.J., Schweimer, K., Schwab, W., Rösch, P., and Hartl-Spiegelhauer, O., Biochem. J., 2014, vol. 457, pp. 379–390.

    Article  CAS  Google Scholar 

  33. Mogensen, J.E., Ferreras, M., Wimmer, R., Petersen, S.V., Enghild, J.J., and Otzen, D.E., Biochemistry, 2007, vol. 46, pp. 3356–3365.

    Article  CAS  PubMed  Google Scholar 

  34. Sliwiak, J., Dolot, R., Michalska, K., Szpotkowski, K., Bujacz, G., Sikorski, M., and Jaskolski, M., J. Struct. Biol., 2016, vol. 193, pp. 55–66.

    Article  CAS  PubMed  Google Scholar 

  35. Bogdanov, I.V., Finkina, E.I., Balandin, S.V., Melnikova, D.N., Stukacheva, E.A., and Ovchinnikova, T.V., Acta Naturae, 2015, vol. 7, pp. 65–73.

    Article  CAS  Google Scholar 

  36. Ishibashi, M., Yoshikawa, H., and Uno, Y., Int. J. Mol. Sci., 2017, vol. 18, p. 3390. doi 10.3390/ijms18061186

    Google Scholar 

  37. Chen, C., Chen, G., Hao, X., Cao, B., Chen, Q., Liu, S., and Lei, J., Plant Sci., 2011, vol. 181, pp. 439–448.

    Article  CAS  PubMed  Google Scholar 

  38. Tsuboi, S., Osafune, T., Tsugeki, R., Nishimura, M., and Yamada, M., J. Biochem., 1992, vol. 111, pp. 500–508.

    Article  CAS  PubMed  Google Scholar 

  39. Pagnussat, L., Burbach, C., Baluska, F., and De La Canal L., J. Exp. Bot., 2012, vol. 63, pp. 6555–6563.

    Article  CAS  PubMed  Google Scholar 

  40. Crimi, M., Astegno, A., Zoccatelli, G., and Esposti, M.D., Arch. Biochem. Biophys., 2006, vol. 445, pp. 65–71.

    Article  CAS  PubMed  Google Scholar 

  41. Casanal, A., Zander, U., Munoz, C., Dupeux, F., Luque, I., Botella, M.A., Schwab, W., Valpuesta, V., and Marquez, J.A., J. Biol. Chem., 2013, vol. 288, pp. 35322–35332.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Hurlburt, B.K., Offermann, L.R., McBride, J.K., Majorek, K.A., Maleki, S.J., and Chruszcz, M., J. Biol. Chem., 2013, vol. 288, pp. 36890–36901.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Salminen, T.A., Eklund, D.M., Joly, V., Blomqvist, K., Matton, D.P., and Edqvist, J., Plants (Basel), 2018, vol. 7. doi 10.3390/plants7010006

    Google Scholar 

  44. Finkina, E.I., Melnikova, D.N., Bogdanov, I.V., and Ovchinnikova, T.V., Curr. Med. Chem., 2017, vol. 24, pp. 1772–1787.

    Article  CAS  PubMed  Google Scholar 

  45. Balsamo, R.A., Wang, J.-L., Eckard, K.J., Wang, C.-S., and Lord, E.M., Protoplasma, 1995, vol. 189, pp. 17–25.

    Article  CAS  Google Scholar 

  46. Zhang, D., Liang, W., Yin, C., Zong, J., Gu, F., and Zhang, D., Plant Physiol., 2010, vol. 154, pp. 149–162.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Park, S.Y., Jauh, G.Y., Mollet, J.C., Eckard, K.J., Nothnagel, E.A., Walling, L.L., and Lord, E.M., Plant Cell, 2000, vol. 12, pp. 151–164.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Chae, K., Kieslich, C.A., Morikis, D., Kim, S.-C., and Lord, E.M., Plant Cell, 2009, vol. 21, pp. 3902–3914.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Choi, Y.E., Lim, S., Kim, H.-J., Han, J.Y., Lee, M.-H., Yang, Y., Kim, J.-A., and Kim, Y.-S., Plant J., 2012, vol. 70, pp. 480–491.

    Article  CAS  PubMed  Google Scholar 

  50. Wang, X., Wang, H., Li, Y., Cao, K., and Ge, X., Mol. Biol. Rep., vol. 36, pp. 745–750.

  51. Choi, D.S., Hwang, I.S., and Hwang, B.K., Plant Cell, 2012, vol. 24, pp. 1675–1690.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Santi, C., Molesini, B., Guzzo, F., Pii, Y., Vitulo, N., and Pandolfini, T., Genes (Basel), 2017, vol. 8. doi 10.3390/genes8120396

    Google Scholar 

  53. Lei, L., Chen, L., Shi, X., Li, Y., Wang, J., Chen, D., Xie, F., and Li, Y., Plant Physiol., 2014, vol. 164, pp. 1045–1058.

    Article  CAS  PubMed  Google Scholar 

  54. Zhang, N., Zhang, S., Borchert, S., Richardson, K., and Schmid, J., Mol. Plant. Microbe. Interact., 2011, vol. 24, pp. 984–992.

    Article  CAS  PubMed  Google Scholar 

  55. Kobayashi, Y., Motose, H., Iwamoto, K., and Fukuda, H., Plant Cell Physiol., 2011, vol. 52, pp. 1095–1106.

    Article  CAS  PubMed  Google Scholar 

  56. Ma, T., Ma, H., Zhao, H., Qi, H., and Zhao, J., BMC Plant Biol., 2014, vol. 14. doi 10.1186/s12870-014-0299-y

    Google Scholar 

  57. Benning, U.F., Tamot, B., Guelette, B.S., and ·Hoffmann-Benning, S., Front. Plant Sci., 2012, vol. 3. doi 10.3389/fpls.2012.00053

    Google Scholar 

  58. Guelette, B.S., Benning, U.F., and Hoffmann-Benning, S., J. Exp. Bot., 2012, vol. 63, pp. 3603–3616.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Mitton, F.M., Pinedo, M.L., and de la Canal, L., J. Plant Physiol., 2009, vol. 166, pp. 543–547.

    Article  CAS  PubMed  Google Scholar 

  60. Thierse, H.J., Gamerdinger, K., Junkes, C., Guerreiro, N., and Weltzien, H.U., Toxicology, 2005, vol. 209, pp. 101–107.

    Article  CAS  PubMed  Google Scholar 

  61. Divkovic, M., Pease, C.K., Gerberick, G.F., and Basketter, D.A., Contact Dermatitis, 2005, vol. 53, pp. 189–200.

    Article  CAS  PubMed  Google Scholar 

  62. Bohle, B., Mol. Nutr. Food Res., 2004, vol. 8, pp. 424–433.

    Article  Google Scholar 

  63. Agea, E., Russano, A., Bistoni, O., Mannucci, R., Nicoletti, I., Corazzi, L., Postle, A.D., De Libero, G., Porcelli, S.A., and Spinozzi, F., J. Exp. Med., 2005, vol. 202, pp. 295–308.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Del Moral, M.G. and Martinez-Naves, E., Immune Netw., 2017, vol. 17, pp. 133–143.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Bublin, M., Eiwegger, T., and Breiteneder, H., J. Allergy Clin. Immunol., 2014, pp. 521–529.

    Google Scholar 

  66. Vassilopoulou, E., Rigby, N., Moreno, F.J., Zuidmeer, L., Akkerdaas, J., Tassios, I., Papadopoulos, N.G., Saxoni-Papageorgiou, P., Ronald van Ree, and Mills, C., J. Allergy Clin. Immunol., 2006, vol. 118, pp. 473–480.

    Article  CAS  PubMed  Google Scholar 

  67. Abdullah, S.U., Alexeev, Y., Johnson, P.E., Rigby, N.M., Mackie, A.R., Dhaliwal, B., and Mills, E.N.C., Sci. Rep., 2016, vol. 6. doi 10.1038/srep30279

    Google Scholar 

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Authors and Affiliations

  1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 119779, Russia

    D. N. Melnikova, E. I. Finkina, I. V. Bogdanov & T. V. Ovchinnikova

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  1. D. N. Melnikova
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  2. E. I. Finkina
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  3. I. V. Bogdanov
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  4. T. V. Ovchinnikova
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Correspondence to T. V. Ovchinnikova.

Additional information

The paper is published based on the materials of a report presented at the “Lipids of the XXI Century. The First Quarter” conference, October 22–23, 2018, Moscow.

Original Russian Text © D.N. Melnikova, E.I. Finkina, I.V. Bogdanov, T.V. Ovchinnikova, 2018, published in Bioorganicheskaya Khimiya, 2018, Vol. 44, No. 6, pp. 585–594.

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Melnikova, D.N., Finkina, E.I., Bogdanov, I.V. et al. Plant Pathogenesis-Related Proteins Binding Lipids and Other Hydrophobic Ligands. Russ J Bioorg Chem 44, 586–594 (2018). https://doi.org/10.1134/S1068162018060055

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