Abstract
We describe an automated mass spectrometer for diagnostics of deceases from the composition of exhaled air. It includes a capillary system, which performs a rapid direct feeding of the sample to the instrument without changing substantially its composition and serves for studying the dynamics of variation of the ratio between various components of exhaled air. The membrane system for introducing the sample is intended for determining low concentrations of volatile organic compounds which are biomarkers of pathologies. It is characterized by selective transmittance and ensures the detection limits of target compounds at the parts per million–parts per billion (ppm–ppb) level. A static mass analyzer operating on permanent magnets possesses advantages important for mobile devices as compared to its dynamic analogs: it is more reliable in operation, has a larger dynamic range, and can be used for determining the concentration of components in the mixture one-by-one or simultaneously. The curvilinear output boundary of the magnetic lens of the mass analyzer makes it possible to reduce its weight and size by 2.5 times without deteriorating the mass resolution. We report on the results of testing of the instrument and consider the possibility of its application for early detection of deceases of respiratory and blood circulation system, gastrointestinal tract, and endocrine system.
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Original Russian Text © V.T. Kogan, A.V. Kozlenok, Yu.V. Chichagov, A.S. Antonov, D.S. Lebedev, A.A. Bogdanov, V.S. Moroshkin, A.V. Berezina, O.S. Viktorova-Leclerc, S.A. Vlasov, Yu.V. Tubol’tsev, 2015, published in Zhurnal Tekhnicheskoi Fiziki, 2015, Vol. 85, No. 10, pp. 135–140.
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Kogan, V.T., Kozlenok, A.V., Chichagov, Y.V. et al. Small-size mass spectrometer for determining gases and volatile compounds in air during breathing. Tech. Phys. 60, 1549–1555 (2015). https://doi.org/10.1134/S1063784215100175
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DOI: https://doi.org/10.1134/S1063784215100175