Abstract
In cell environments crowded with macromolecules, the depletion effects act and assist in the assembly of a wide range of cellular structures, from the cytoskeleton to the chromatin loop, which are well accepted. But a recent quantum dot experiment indicated that the dimensions of the receptor–ligand complex have strong effects on the size-dependent exclusion of proteins in cell environments. In this article, a continuum elastic model is constructed to resolve the competition between the dimension of the receptor–ligand complex and depletion effects in the endocytosis of a spherical virus-like bioparticle. Our results show that the depletion effects do not always assist endocytosis of a spherical virus-like bioparticle; while the dimension of the ligand–receptor complex is larger than the size of a small bioparticle in cell environments, the depletion effects do not work and reverse effects appear. The ligand density covered on the virus can be identified quantitatively.
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Wang, C., Liu, Y., Fan, Y. et al. Reverse depletion effects and the determination of ligand density on some spherical bioparticles. J. Exp. Theor. Phys. 122, 1117–1121 (2016). https://doi.org/10.1134/S1063776116050228
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DOI: https://doi.org/10.1134/S1063776116050228