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Evolutionary and Ontogenetic Plasticity of Conserved Signaling Pathways in Animals’ Development

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Abstract—

The view that the signaling pathways involved in the regulation of animals’ key developmental processes (body axis formation, germ layers’ specification, embryonic induction) are highly conservative, dominates in Evolutionary Developmental Biology (EvoDevo). At the same time, there are many pieces of evidence that these signaling pathways are extremely flexible. In this review, the evolutionary and ontogenetic plasticity of signaling cascades operating in the development of several model species are analyzed. Studies of the plasticity of molecular mechanisms of regulation of ontogenesis are necessary for understanding the basic principles of animal evolution as well as for the introduction and improvement of applied biomedical technologies. This review will allow readers to look at the concept of “conservatism” of molecular regulatory mechanisms in animal ontogeny and evolution from different angles.

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Funding

The work was carried out with the support of the Russian Foundation for Basic Research, Expansion grant, no. 20-14-50526. The work was performed within the framework of the State Assignment of the Koltsov Institute of Developmental Biology, Russian Academy of Sciences, 2021, no. SA 0088-2021-0009 and the scientific project of the State Assignment of Moscow State University, no. 121032300066-4.

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  1. Department of Embryology, Faculty of Biology, Moscow State University, 119923, Moscow, Russia

    S. V. Kremnev

  2. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334, Moscow, Russia

    S. V. Kremnev

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  1. S. V. Kremnev
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Correspondence to S. V. Kremnev.

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The author declares that he has no conflicts of interest. This article does not contain any studies involving animals or human participants performed by the author.

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Translated by A. Ermakov

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Kremnev, S.V. Evolutionary and Ontogenetic Plasticity of Conserved Signaling Pathways in Animals’ Development. Russ J Dev Biol 53, 65–81 (2022). https://doi.org/10.1134/S1062360422020114

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