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Some Aspects Related to Transmission of Radiation-Induced Alterations due to the Bystander Effect

  • GENERAL RADIOBIOLOGY
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Abstract

This paper presents the first results of research and observations within the framework of the Integrated Project for the assessment of radiation-induced nontargeted effects. The remote bystander effect, related to nontargeted effects, is one of the least studied phenomena in terms of manifestations and mechanisms. The international laboratory practice with respect to this phenomenon commenced with demonstration of the bystander effect in fish and other aquacultures. Our studies have revealed changes similar to radiation-induced pathologies in nonirradiated mice kept for three months in contact with the irradiated species (exposed to a 3 Gy γ-ray dose). Changes in behavioral responses, a statistically significant trend for decreasing spleen weight (r = –0.416; p = 0.048), an expanding area of alopecia (r = –0.631; p = 0.001), and other anomalies are noted. Discussions on possible mechanisms of the phenomena refer to both A.M. Kuzin’s theory of radiotoxins (1966) and the interpretation of the hypotheses investigated by C. Mothersill (2010–2019). An assumption is made on the important role of derivatives of lipid peroxides in the formation of this effect. The results of these studies indicate the need for further investigation of the radiation-induced bystander effect by using the molecular and cellular methodological approaches.

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Funding

This work was supported by the Russian Foundation for Basic Research, project no. 16-04-00963/18. It was conducted in part within the framework of a State Assignment of the Ministry of Education and Science of the Russian Federation (topic no. 0082-2014-0001, no. AAAA-A17-117040610310-6) and financially supported by a subsidy allocated by the Institute of Chemical Physics, Russian Academy of Sciences, for implementation of the State Assignment, topic no. 0082-2014-0001 “Study of Principles of the Structural and Functional Organization of Biomolecular Systems, the Development of Methods for Design of Their Physicochemical Analogues, and Creation of Biologically Active Preparations of a New Generation,” project no. AAAA-A17-117040610310-6.

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Authors and Affiliations

  1. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, 119991, Moscow, Russia

    V. V. Petushkova, I. I. Pelevina, I. N. Kogarko, E. A. Neifakh, B. S. Kogarko & O. V. Ktitorova

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  1. V. V. Petushkova
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  2. I. I. Pelevina
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  3. I. N. Kogarko
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  4. E. A. Neifakh
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  5. B. S. Kogarko
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Correspondence to V. V. Petushkova.

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Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. The experimental procedures were conducted in accordance with the relevant international guidelines for working with animals [19].

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Translated by M. Romanova

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Petushkova, V.V., Pelevina, I.I., Kogarko, I.N. et al. Some Aspects Related to Transmission of Radiation-Induced Alterations due to the Bystander Effect. Biol Bull Russ Acad Sci 47, 1610–1617 (2020). https://doi.org/10.1134/S1062359020120079

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