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Analysis of Incidence Risk for Different Types of Stroke among the Mayak Worker Cohort

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Abstract

The incidence risk estimates for different types of strokes among the cohort of 22 377 Mayak workers occupationally exposed to prolonged radiation and followed up until the end of 2013 are presented. Information about the work histories and estimates of the liver absorbed doses from external and internal radiations were obtained from the “Mayak Worker Dosimetry System—2013” database; medical data and lifestyle factors were obtained from the “Clinic” medical and dosimetry database. Over the entire follow-up period, 221 cases of intracerebral hemorrhage (ICH), 1463 cases of brain cerebral infarction (BI), and 342 cases of nonspecified stroke (NS) were registered in the study cohort. It was shown that the ICH, BI, and NS incidence risks in the study cohort were significantly associated with nonradiation factors such as gender, age, calendar period, duration of employment at the main plants, smoking, alcohol assumption, body mass index, and comorbidities (arterial hypertension and diabetes), which agreed with the literature data. Analyses did not reveal an effect of external γ-ray exposure on the ICH and BI incidence. However, NS relative risk (RR) was statistically significantly below the one in the groups of workers exposed to external γ-rays at the total absorbed liver doses above 0.20 Gy as compared with workers exposed at doses below 0.10 Gy. BI incidence RR was statistically significantly above the one in the groups of workers exposed to internal α-radiation at the total absorbed liver dose above 0.10 Gy as compared with workers exposed at lower doses. There was no effect of internal exposure on the ICH and NS incidence. These findings agreed with the results obtained earlier for the Mayak worker cohort.

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Notes

  1. Here and below the data are presented as the mean (standard deviation).

  2. The value of BMI calculated as mass in kilograms divided by height in meters raised to the second power and equal to 18.5–24.99 kg/m2 was considered as normal.

  3. It was considered that the AH was the state, in which the arterial blood pressure was more than 140/90 mmHg.

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Authors and Affiliations

  1. Southern Urals Biophysics Institute, Russian Federal Medical Biological Agency, Ozyorsk, Russia

    M. B. Moseeva, E. S. Grigoryeva & T. V. Azizova

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  1. M. B. Moseeva
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  2. E. S. Grigoryeva
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  3. T. V. Azizova
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Correspondence to T. V. Azizova.

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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by L. Solovyova

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Moseeva, M.B., Grigoryeva, E.S. & Azizova, T.V. Analysis of Incidence Risk for Different Types of Stroke among the Mayak Worker Cohort. Biol Bull Russ Acad Sci 47, 1516–1523 (2020). https://doi.org/10.1134/S1062359020110102

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