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Change in Urine Odor of Mice in the Dynamics of Formation of a Transplanted Hepatocarcinoma H33 Tumor

  • ANIMAL AND HUMAN PHYSIOLOGY
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Abstract—

The effect of the stage of development of a malignant tumor on successful detection in the urine of animals with oncology by dogs was studied. It was demonstrated that the success of dogs in the search for sick organisms among healthy ones is quite consistent with the dynamics of the development of transplanted tumor tissue; that is, dogs are able to perceive both the entire spectrum of volatile metabolites accompanying the disease and changes in this spectrum associated directly with the development of the tumor. The existence of volatile organic compounds associated with the growth of a malignant tumor was established.

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Authors and Affiliations

  1. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, 127051, Moscow, Russia

    M. Yu. Kochevalina, V. G. Trunov & E. I. Rodionova

  2. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, 115478, Moscow, Russia

    O. V. Morozova

  3. Cynological Monitoring Division of the Aviation Security Management Department, PAO Aeroflot–Russian Airlines, 119002, Moscow, Russia

    G. A. Kogun

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  1. M. Yu. Kochevalina
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  2. V. G. Trunov
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Kochevalina, M.Y., Trunov, V.G., Morozova, O.V. et al. Change in Urine Odor of Mice in the Dynamics of Formation of a Transplanted Hepatocarcinoma H33 Tumor. Biol Bull Russ Acad Sci 47, 506–513 (2020). https://doi.org/10.1134/S1062359020050052

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