Abstract
It is shown that the effect of 5-fluorouracil (5-FU) on mesenchymal stromal cells (MSCs) of the bone marrow and fetal liver of the rat enriches the population with cells with a reduced proliferative potential. It is shown that, in the course of passaging, the 5-FU-resistant MSCs of the bone marrow and fetal liver lose their ability to differentiate in the osteogenic direction more and less rapidly, respectively, than the 5-FU-sensitive MSCs.
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Original Russian Text © O.V. Payushina, N.N. Butorina, O.N. Sheveleva, E.I. Domaratskaya, 2015, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2015, No. 3, pp. 258–264.
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Payushina, O.V., Butorina, N.N., Sheveleva, O.N. et al. Comparative analysis of subpopulations of mesenchymal stromal cells of the bone marrow and fetal liver differing in sensitivity to 5-fluorouracil. Biol Bull Russ Acad Sci 42, 206–212 (2015). https://doi.org/10.1134/S1062359015030097
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DOI: https://doi.org/10.1134/S1062359015030097