Abstract
After completing the Program for the Destruction of Chemical Weapons (CW) in September 2017, the Russian Federation converts CW destruction facilities for their further use for civilian purposes. An essential measure in the reprofiling of these facilities is the assessment of possible residual contamination and the identification of unrecorded facts of contamination with toxic organophosphorus substances (organophosphorus toxicants, OPTs) or reaction masses (RM) from the neutralization of the infrastructure of the former CW destruction facilities. This paper presents a procedure for a multipurpose screening of 11 conversion products of three OP nerve agents: O-isobutyl-S-(2-diethylaminoethyl)methylphosphonothioate (VR), isopropyl ester of methylphosphonofluoridic acid (Sarin, GB), pinacolyl ester of methylphosphonofluoridic acid (Soman, GD), and VR itself (as the most persistent OP nerve agents) in construction materials. Screening of all analytes, significantly differing in their physicochemical properties, is carried out within single analysis by high-performance liquid chromatography with tandem mass-selective detection (HPLC–MS/MS). A procedure is proposed for the collection of wipe samples from surfaces and solid samples of construction materials with various matrix composition.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Vasil’ev, I.A., Shvyriev, B.V., and Liberman, B.M., et al., Ross. Khim. Zh., 1995, vol. 39, no. 4, p. 10.
Demidyuk, V.V., Kalugin, G.D., Petrunin, V.A., et al., Sovremennaya rossiiskaya dvukhstadiinaya tekhnologiya bezopasnogo, nadezhnogo i ekonomicheski chistogo unichtozheniya khimicheskogo oruzhiya (Modern Russian Two-stage Technology for the Safe, Reliable and Economic Clean Destruction of Chemical Weapons), Demidyuk, V.V., Ed., Moscow: GosNIIOHT, 1997.
Demiduk, V.V., Shalganova, I.V., and Shirokov, A.U., Ecological and hygienic characteristics of the Russian two-stage technology of chemical detoxification of Sarin, Soman, V-gases (Preliminary report), Moscow, 1998, p. 30.
Savel’eva, E.I., Zenkevich, I.G., Kuznetsova, T.A., et al., Ross. Khim. Zh., 2002, vol. 46, no. 6, p. 82.
Green, U., Kremer, J.H., Zillmer, M., et al., Environ. Toxicol., 2003, vol. 18, p. 368.
Popiel, S. and Sankowska, M., J. Chromatogr. A, 2011, vol. 1218, p. 8457.
Crenshaw, M.D., Hayes, T.L., Miller, T.L., et al., J. Appl. Toxicol., 2001, vol. 21, p. 53.
Gulyaev, D.V., Kombarova, M.U., Radilov, A.S., et al., Med. Ekstrem. Sit, 2019, no. 4, p. 556.
Savel’eva, E.I., Zenkevich, I.G., and Radilov, A.S., J. Anal. Chem., 2003, vol. 58, no. 2, p. 135.
Munro, N.B., Talmage, S.S., Griffin, G.D., et al., Environ. Health Perspect., 1999, vol. 107, no. 12, p. 933.
Creasy, W.R., Stuff, J.R., Williams, B., et al., J. Chromatogr. A, 1997, vol. 774, p. 253.
Rohrbaugh, D.R., J. Chromatogr. A, 1998, vol. 809, p. 131.
Brickhouse, M.D., Creasy, W.R., Williams, B.R., et al., J. Chromatogr. A, 2000, vol. 883, p. 185.
Savel’eva, E.I., Radilov, A.S., Kuznetsova, T.A., et al., J. Appl. Chem., 2001, vol. 74, no. 10, p. 1671.
Baygildiev, T.M., Vokuev, M.F., Oreshkin, D.V., et al., J. Anal. Chem., 2020, vol. 75, no. 13, p. 1708.
Rodin, I.A., Braun, A.V., Baygildiev, T.M., et al., J. Anal. Chem., 2015, vol. 70, no. 14, p. 1671.
Young, S.A. and Capacio, B.R., J. Anal. Toxicol., 2019, vol. 43, no. 3, p. 179.
D’Agostino, P.A., Hancock, J.R., Chenier, C.L., et al., J. Chromatogr. A, 2006, vol. 1110, p. 86.
Weissberg, A., Madmon, M., Elgarisi, M., et al., J. Chromatogr. A, 2018, vol. 23, p. 24.
Munro, N., Ambrose, K., and Watson, A., Environ. Health Perspect., 1994, vol. 102, p. 18.
1-Isobutyl-3-Methylbutyl Isopropylphosphonofluoridate. http://www.opcw.org/sites/default/files/documents/2019/08/Handbook%20on%20Chemicals_2019.pdf. Accessed May 25, 2021.
SanPiN (Hygienic Standards and Requirements) 1.2.3685-21: Hygienic Standards and Requirements for Ensuring Safety and (or) Harmlessness to Humans from Environmental Factors, Moscow, 2021. https://meganorms.com/sanpin-1-2-3685-21.html. Accessed May 25, 2021.
Savel’eva, E.I., Leninskii, M.A., Vasil’eva, I.A., et al., Anal. Kontrol’, 2021, vol. 25, no. 3, p. 43.
Wils, E.R.J., in Chemical Weapons Convention Analysis, Sample Collection, Preparation and Analytical Methods, Mesilaakso, M., Ed., Chichester: Wiley, 2005, p. 249.
Pardasani, D., Tak, V., Purohit, A.K., et al., Eur. J. Mass Spectrom., 2011, vol. 17, p. 57.
Taka, V., Purohita, A., Pardasania, D., et al., J. Chromatogr. A, 2014, vol. 1370, p. 80.
Wilson, S.A., Anal. Chem., 2015, vol. 87, p. 1034.
Baygildiev, T.M., Rodin, I.A., Stavrianidi, A.N., et al., Inorg. Mater., 2017, vol. 53, no. 14, p. 1382.
Mil’man, B.L. and Jurkovich, I.K., Anal. Kontrol’, 2020, vol. 24, no. 3, p. 164.
Leninskii, M.A., Savel’eva, E.I., and Vasil’eva, I.A., Chem. Saf., 2021, vol. 5, no. 1, p. 166.
Funding
The study was performed without sponsorship.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
The authors declare that they have no conflicts of interest.
Additional information
Translated by O. Zhukova
Rights and permissions
About this article
Cite this article
Leninskii, M.A., Savelieva, E.I., Karakashev, G.V. et al. Determination of the Conversion Products of Toxic organophosphorus substances in Construction Materials Using High-Performance Liquid Chromatography with Tandem Mass Spectrometry. J Anal Chem 77, 1694–1704 (2022). https://doi.org/10.1134/S1061934822130020
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1061934822130020