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Separation of 2-Pentanol Racemate on a Chiral Stationary Phase Based on Homochiral NiSO4·6H2O Crystals Obtained under Viedma Ripening

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Abstract

A new chiral stationary phase based on homochiral crystals of α-NiSO4∙6H2O obtained under the condition of Viedma ripening is proposed for the separation of 2-pentanol racemate. The retention times and separation parameters are determined from chromatograms of the separation of 2-pentanol racemate. Separation occurs in the concentration range 4–11.3 mg/mL (eluent is a mixture of n-heptane and chloroform). The reliability of the separation is confirmed by polarimetry and the gas-chromatographic analysis of the fractions of each peak with mass-spectrometric detection. It is shown that the separation parameters do not depend on the elution rate. With an increase in the volume fraction of chloroform, the eluting force increases, and the separation criterion and the selectivity coefficient decrease. The latter range from 1.09 to 1.32. The maximum separation efficiency was 2000 tp/m. The proposed stationary phase can be used for the semi-preparative separation of ennatiomers.

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Funding

This work was supported by the Russian Science Foundation, project no. 19-73-10079.

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Authors and Affiliations

  1. Bashkir State University, 450076, Ufa, Bashkortostan, Russia

    Yu. F. Sharafutdinova, A. Sh. Ganieva & V. Yu. Gus’kov

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  1. Yu. F. Sharafutdinova
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  2. A. Sh. Ganieva
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  3. V. Yu. Gus’kov
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Correspondence to Yu. F. Sharafutdinova.

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Translated by V. Kudrinskaya

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Sharafutdinova, Y.F., Ganieva, A.S. & Gus’kov, V.Y. Separation of 2-Pentanol Racemate on a Chiral Stationary Phase Based on Homochiral NiSO4·6H2O Crystals Obtained under Viedma Ripening. J Anal Chem 76, 1093–1097 (2021). https://doi.org/10.1134/S1061934821090100

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  • DOI: https://doi.org/10.1134/S1061934821090100

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