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Determination of Zoledronic Acid and Creatinine by Hydrophilic Chromatography

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Abstract

We propose a version of the simultaneous determination of zoledronic acid and creatinine in serum and plasma samples by hydrophilic chromatography (HILIC). Factors affecting the determination of zoledronic acid were found: the composition and concentration of the buffer solution, the nature of the stationary phase, the presence of tartaric acid in the eluent as a complexing agent to prevent the complexation of zoledronic acid with metal ions. We determined the linear concentration ranges for zoledronic acid and creatinine and their limits of detection. The following conditions for chromatographic analysis were found: amide stationary phase; a 5 mM phosphate buffer solution, 2 mM tartaric acid (pH 7.0)/CH3CN; gradient 90–70% of CH3CN.

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ACKNOWLEDGMENTS

The authors are grateful to the Chemical Analysis and Materials Research Centre of the Research Park of the St. Petersburg State University for the equipment provided.

Funding

This work was supported by the Russian Foundation for Basic Research, project no. 18-53-80010 BRICS_t.

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Authors and Affiliations

  1. Institute of Chemistry, St. Petersburg State University, 198504, St. Petersburg, Russia

    L. A. Kartsova, V. D. Somova & E. A. Bessonova

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  1. L. A. Kartsova
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  2. V. D. Somova
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  3. E. A. Bessonova
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Corresponding author

Correspondence to L. A. Kartsova.

Additional information

Translated by O. Zhukova

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Kartsova, L.A., Somova, V.D. & Bessonova, E.A. Determination of Zoledronic Acid and Creatinine by Hydrophilic Chromatography. J Anal Chem 76, 221–225 (2021). https://doi.org/10.1134/S1061934821020106

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  • DOI: https://doi.org/10.1134/S1061934821020106

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