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Determination of Methionine in Medicines by Stripping Voltammetry

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Abstract

A method is proposed for the determination of methionine by stripping voltammetry on a carbon-containing electrode modified by vitamin B12. The procedure is based on the reaction of methionine reduction to homocysteine. The preparation of the electrode consists in the formation of a vitamin B12 film on the surface of a carbon-containing electrode modified with carbon nanotubes by cyclic voltammetry with a potential sweep from –1.4 to +1 V. The conditions of analysis are optimized: accumulation potential, accumulation time, and sweep rate. The limit of detection for methionine is 1 × 10–7 M.

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Authors and Affiliations

  1. Chemical Faculty, National Research Tomsk State University, 634050, Tomsk, Russia

    V. V. Shelkovnikov, A. M. Altyev & M. E. Vinogradov

Authors
  1. V. V. Shelkovnikov
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  2. A. M. Altyev
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  3. M. E. Vinogradov
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Correspondence to V. V. Shelkovnikov.

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Translated by V. Kudrinskaya

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Shelkovnikov, V.V., Altyev, A.M. & Vinogradov, M.E. Determination of Methionine in Medicines by Stripping Voltammetry. J Anal Chem 74, 1239–1244 (2019). https://doi.org/10.1134/S1061934819120116

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  • DOI: https://doi.org/10.1134/S1061934819120116

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