Skip to main content
Log in

Application of Chromatographic and Electrophoretic Techniques to Metabolomic Studies

  • REVIEWS
  • Published:
Journal of Analytical Chemistry Aims and scope Submit manuscript

Abstract

A living organism is a biochemically unique system, and its vital functions can be investigated using analytical measurements. Characteristic chromatographic or electrophoretic profiles of biologically active substances have been the objects of active biomedical research for more than 15 years because of the possibility of rapidly obtaining diagnostically important information. In this review, targeted and untargeted metabolomic studies performed by chromatography and capillary electrophoresis are considered.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.

Similar content being viewed by others

REFERENCES

  1. Sniehotta, M., Schiffer, E., Zurbig, P., Novak, J., and Mischak, H., Electrophoresis, 2007, vol. 28, no. 9, p. 1407.

    Article  CAS  PubMed  Google Scholar 

  2. Kartsova, L.A. and Ob”edkova, E.V., J. Anal. Chem., 2013, vol. 68, no. 4, p. 291.

    Article  CAS  Google Scholar 

  3. Kartsova, L.A. and Bessonova, E.A., Russ. Chem. Rev., 2015, vol. 84, no. 8, p. 860.

    Article  CAS  Google Scholar 

  4. Williams, R.J., Biochemical Institute Studies IV. Individual Metabolic Patterns and Human Disease: An Exploratory Study Utilizing Predominantly Paper Chromatographic Methods, Austin, TX: Univ. Texas, 1951, p. 7.

    Google Scholar 

  5. Young, D.S., Am. J. Clin. Pathol., 1970, vol. 53, p. 803.

    CAS  PubMed  Google Scholar 

  6. Burtis, C.A., Goldstein, G., and Scott, C.D., Clin. Chem., 1970, vol. 16, no. 3, p. 201.

    CAS  PubMed  Google Scholar 

  7. Williams, G.Z., Young, D.S., Stein, M.R., and Cotlove, E., Clin. Chem., 1970, vol. 16, no. 12, p. 1016.

    CAS  PubMed  Google Scholar 

  8. Pauling, L., Robinson, A.B., Teranishi, R., and Cary, P., Proc. Natl. Acad. Sci. U. S. A., 1971, vol. 68, no. 10, p. 2374.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Horning, E.C. and Horning, M.G., Clin. Chem., 1971, vol. 17, no. 8, p. 802.

    CAS  PubMed  Google Scholar 

  10. Hoult, D.I., Busby, S.J., Gadian, D.G., Radda, G.K., Richards, R.E., and Seeley, P.J., Nature, 1974, vol. 252, no. 5481, p. 285.

    Article  CAS  PubMed  Google Scholar 

  11. Dolnik, V. and Dolnikov, J., J. Chromatogr. A, 1995, vol. 716, nos. 1–2, p. 269.

    Article  CAS  PubMed  Google Scholar 

  12. Johnson, C.H., Ivanisevic, J., and Siuzdak, G., Nat. Rev. Mol. Cell Biol., 2016, vol. 17, no. 7, p. 451.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Griffiths, W.J., Koal, T., Wang, Y., Kohl, M., Enot, D.P., and Deigner, H.P., Angew. Chem., Int. Ed. Engl., 2010, vol. 49, no. 32, p. 5426.

    Article  CAS  Google Scholar 

  14. Alonso, A., Marsal, S., and Julià, A., Front. Bioeng. Biotechnol., 2015, vol. 3, p. 23.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Oliver, S.G., Winson, M.K., Kell, D.B., and Ba-ganz, F., Trends Biotechnol., 1998, vol. 16, no. 9, p. 373.

    Article  CAS  PubMed  Google Scholar 

  16. Wishart, D.S., Nat. Rev. Drug Discovery, 2016, vol. 15, no. 7, p. 473.

    Article  CAS  PubMed  Google Scholar 

  17. Dedov, I.I., Tyul’pakov, A.N., Chekhonin, V.P., Baklaushev, V.P., Archakov, A.I., and Moshkovskii, S.A., Vestn. Ross. Akad. Med. Nauk, 2012, vol. 67, no. 12, p. 4.

    Article  Google Scholar 

  18. Kim, H.-J., Seo, K.-A., Kim, H.-M., Jeong, E.-S., Ghim, J.L., Lee, S.H., Lee, Y.M., Kim, D.H., and Shin, J.-G., J. Pharm. Biomed. Anal., 2015, vol. 102, p. 9.

    Article  CAS  PubMed  Google Scholar 

  19. Gowda, G.N., Zhang, S., Gu, H., Asiago, V., Shanaiah, N., and Raftery, D., Expert Rev. Mol. Diagn., 2008, vol. 8, no. 5, p. 617.

    Article  CAS  PubMed  Google Scholar 

  20. Kobayashi, T., Yoshida, T., Fujisawa, T., Matsumura, Y., Ozawa, T., Yanai, H., Iwasawa, A., Kamachi, T., Fujiwara, K., Kohno, M., and Tanaka, N., Biochem. Biophys. Res. Commun., 2014, vol. 445, no. 2, p. 412.

    Article  CAS  PubMed  Google Scholar 

  21. Wang, W., Feng, B., Li, X., Yin, P., Gao, P., Zhao, X., Lu, X., Zheng, M., and Xu, G., Mol. Biosyst., 2010, vol. 6, no. 10, p. 1947.

    Article  CAS  PubMed  Google Scholar 

  22. Shah, V.O., Townsend, R.R., Feldman, H.I., Pappan, K.L., Kensicki, E., and Vander Jagt D.L., Clin. J. Am. Soc. Nephrol., 2013, vol. 8, no. 3, p. 363.

    Article  CAS  PubMed  Google Scholar 

  23. Armitage, E.G. and Barbas, C., J. Pharm. Biomed. Anal., 2014, vol. 87, p. 1.

    Article  CAS  PubMed  Google Scholar 

  24. Preter, V.D. and Verbeke, K., World J. Gastrointest. Pharmacol. Ther., 2013, vol. 4, no. 4, p. 97.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Weiss, R.H. and Kim, K., Nat. Rev. Nephrol., 2011, vol. 8, no. 1, p. 22.

    Article  CAS  PubMed  Google Scholar 

  26. Rhee, E.P., Curr. Opin. Nephrol. Hypertens., 2015, vol. 24, no. 4, p. 371.

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Egea, R.R., Puchalt, N.G., Escriva, M.M., and Varghese, A.C., J. Hum. Reprod. Sci., 2014, vol. 7, no. 2, p. 73.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Botas, A., Campbell, H.M., Han, X., and Maletic-Savatic, M., Int. Rev. Neurobiol., 2015, vol. 122, p. 53.

    Article  CAS  PubMed  Google Scholar 

  29. Scrivo, R., Casadei, L., Valerio, M., Priori, R., Valesini, G., and Manetti, C., Curr. Allergy Asthma Rep., 2014, vol. 14, no. 6, p. 445.

    Article  CAS  PubMed  Google Scholar 

  30. Guma, M., Tiziani, S., and Firestein, G.S., Nat. Rev. Rheumatol., 2016, vol. 12, no. 5, p. 269.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Kordalewska, M. and Markuszewski, M.J., J. Pharm. Biomed. Anal., 2015, vol. 113, p. 121.

    Article  CAS  PubMed  Google Scholar 

  32. Sas, K.M., Karnovsky, A., Michailidis, G., and Pennathur, S., Diabetes, 2015, vol. 64, no. 3, p. 718.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Preez, I.D., Luies, L., and Loots, D.T., Biomarkers Med., 2017, vol. 11, no. 2, p. 179.

    Article  CAS  Google Scholar 

  34. Goonewardena, S.N., Prevette, L.E., and Desai, A.A., Curr. Atheroscler. Rep., 2010, vol. 12, no. 4, p. 267.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Urpi-Sarda, M., Boto-Ordóñez, M., Queipo-Ortuño, M.I., Tulipani, S., Corella, D., Estruch, R., Tinahones, F.J., and Andres-Lacueva, C., Electrophoresis, 2015, vol. 36, no. 36, p. 2259.

    Article  CAS  PubMed  Google Scholar 

  36. Pujos-Guillot, E., Hubert, J., Martin, J.F., Lyan, B., Quintana, M., Claude, S., Chabanas, B., Roth-well, J.A., Bennetau-Pelissero, C., Scalbert, A., Comte, B., Hercberg, S., Morand, C., Galan, P., and Manach, C., J. Proteome Res., 2013, vol. 12, no. 4, p. 1645.

    Article  CAS  PubMed  Google Scholar 

  37. Wang, M., Chen, L., Liu, D., Chen, H., Tang, D., and Zhao, Y., Chem.-Biol. Interact., 2017, vol. 273, no. 273, p. 133.

    Article  CAS  PubMed  Google Scholar 

  38. Paudel, L., Wyzgoski, F.J., Giusti, M.M., Johnson, J.L., Rinaldi, P.L., Scheerens, J.C., Chanon, A.M., Bomser, J.A., Miller, A.R., Hardy, J.K., and Reese, R.N., J. Agric. Food Chem., 2014, vol. 62, no. 8, p. 1989.

    Article  CAS  PubMed  Google Scholar 

  39. Chen, H.H., Tseng, Y.J., Wang, S.Y., Tsai, Y.S., Chang, C.S., Kuo, T.C., Yao, W.J., Shieh, C.C., Wu, C.H., and Kuo, P.H., Int. J. Obes., 2015, vol. 39, no. 8, p. 1241.

    Article  CAS  Google Scholar 

  40. Chang, A.Y., Lalia, A.Z., Jenkins, G.D., Dutta, T., Carter, R.E., Singh, R.J., and Nair, K.S., Metabolism, 2017, vol. 71, p. 52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Chen, T., He, P., Tan, Y., and Xu, D., Biochem. Biophys. Res. Commun., 2017, vol. 485, no. 1, p. 119.

    Article  CAS  PubMed  Google Scholar 

  42. Medina, S., Ferreres, F., García-Viguera, C., Horcajada, M.N., Orduna, J., Saviron, M., Zurek, G., Martínez-Sanz, J.M., Gil, J.I., and Gil-Izquierdo, A., Food Chem., 2013, vol. 136, no. 2, p. 938.

    Article  CAS  PubMed  Google Scholar 

  43. Rasmussen, L.G., Winning, H., Savorani, F., Toft, H., Larsen, T.M., Dragsted, L.O., Astrup, A., and Engelsen, S.B., Nutrients, 2012, vol. 4, no. 2, p. 112.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Jacobs, D.M., Fuhrmann, J.C., Dorsten, F.A., Rein, D., Peters, S., Velzen, E.J.J., Hollebrands, B., Draijer, R., Duynhoven, J., and Garczarek, U., J. Agric. Food Chem., 2012, vol. 60, no. 12, p. 3078.

    Article  CAS  PubMed  Google Scholar 

  45. Guertin, K., Loftfield, E., Boca, S., Sampson, J., Moore, S., Xiao, Q., Huang, W., Xiong, X., Freedman, N., Cross, A., and Sinha, R., Am. J. Clin. Nutr., 2015, vol. 101, no. 5, p. 1000.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Wittenbecher, C., Muhlenbruch, K., Kroger, J., Jacobs, S., Kuxhaus, O., Floegel, A., Fritsche, A., Pischon, T., Prehn, C., Adamski, J., Joost, H., Boeing, H., and Schulze, M.B., Am. J. Clin. Nutr., 2015, vol. 101, no. 6, p. 1241.

    Article  CAS  PubMed  Google Scholar 

  47. Gao, Y., Lu, Y., Huang, S., Gao, L., Liang, X., Wu, Y., Wang, J., Huang, Q., Tang, L., Wang, G., Yang, F., Hu, S., Chen, Z., Wang, P., Jiang, Q., Huang, R., Xu, Y., Yang, X., and Ong, C.N., Environ. Sci. Technol., 2014, vol. 48, no. 11, p. 6409.

    Article  CAS  PubMed  Google Scholar 

  48. Wang, Z., Zheng, Y., Zhao, B., Zhang, Y., Liu, Z., Xu, J., Chen, Y., Yang, Z., Wang, F., Wang, H., He, J., Zhang, R., and Abliz, Z., J. Proteome Res., 2015, vol. 14, no. 6, p. 2583.

    Article  CAS  PubMed  Google Scholar 

  49. Hecht, S.S., Stepanov, I., and Carmella, S.G., Acc. Chem. Res., 2016, vol. 49, no. 1, p. 106.

    Article  CAS  PubMed  Google Scholar 

  50. Ob”edkova, E.V., Kartsova, L.A., Kirsanov, D.O., Velikanova, L.I., and Legin, A.V., J. Anal. Chem., 2014, vol. 69, no. 2, p. 200.

  51. Rossi, C., Calton, L., Hammond, G., Brown, H.A., Wallace, A.M., Sacchetta, P., and Morris, M., Clin. Chim. Acta, 2010, vol. 411, nos. 3–4, p. 222.

    Article  CAS  PubMed  Google Scholar 

  52. Handelsman, D.J., Teede, H.J., Desai, R., Norman, R.J., and Moran, L.J., Hum. Reprod., 2017, vol. 32, no. 2, p. 418.

    Article  CAS  PubMed  Google Scholar 

  53. Leichtle, A.B., Nuoffer, J., Ceglarek, U., Kase, J., Conrad, T., Witzigmann, H., Thiery, J., and Fiedler, G.M., Metabolomics, 2012, vol. 8, no. 4, p. 643.

    Article  CAS  PubMed  Google Scholar 

  54. Zhao, Q., Cao, Y., Wang, Y., Hu, C., Hu, A., Ruan, L., Bo, Q., Liu, Q., Chen, W., Tao, F., Ren, M., Ge, Y., Chen, A., and Li, L., Asia Pac. J. Clin. Nutr., 2014, vol. 23, no. 3, p. 429.

    CAS  PubMed  Google Scholar 

  55. Kim, H.J., Jang, S.H., Ryu, J.S., Lee, J.E., Kim, Y.C., Lee, M.K., Jang, T.W., Lee, S.Y., Nakamura, H., Nishikata, N., Mori, M., Noguchi, Y., Miyano, H., and Lee, K.Y., Lung Cancer, 2015, vol. 90, no. 3, p. 522.

    Article  PubMed  Google Scholar 

  56. Gu, Y., Chen, T., Fu, S., Sun, X., Wang, L., Lu, Y., Ding, S., Ruan, G., Teng, L., and Wang, M., J. Transl. Med., 2015, vol. 13, no. 35, p. 1.

    Article  CAS  Google Scholar 

  57. Trifonova, O., P., Lokhov, P.G., and Archakov, A.I., Biochemistry (Moscow), Ser. B, 2013, vol. 7, no. 3, p. 179.

    Google Scholar 

  58. Bogdanov, M., Matson, W.R., Wang, L., Matson, T., Saunders-Pullman, R., Bressman, S.S., and Flint Beal, M., Brain, 2008, vol. 131, no. 2, p. 389.

    Article  PubMed  Google Scholar 

  59. Wang, W., Feng, B., Li, X., Yin, P., Gao, P., Zhao, X., Lu, X., Zheng, M., and Xu, G., Mol. Biosyst., 2010, vol. 6, no. 10, p. 1947.

    Article  CAS  PubMed  Google Scholar 

  60. Pears, M.R., Cooper, J.D., Mitchison, H.M., Mortishire-Smith, R.J., Pearce, D.A., and Griffin, J.L., J. Biol. Chem., 2005, vol. 280, no. 52, p. 42508.

    Article  CAS  PubMed  Google Scholar 

  61. Wishart, D.S., Knox, C., Guo, A.C., Eisner, R., Young, N., Gautam, B., Hau, D.D., Psychogios, N., Dong, E., Bouatra, S., Mandal, R., Sinelnikov, I., Xia, J., Jia, L., Cruz, J.A., Lim, E., Sobsey, C.A., Shrivastava, S., Huang, P., Liu, P., Fang, L., Peng, J., Fradette, R., Cheng, D., Tzur, D., Clements, M., Lewis, A., De Souza, A., Zuniga, A., Dawe, M., Xiong, Y., Clive, D., Greiner, R., Nazyrova, A., Shaykhutdinov, R., Li, L., Vogel, H.J., and Forsythe, I., Nucleic Acid Res., 2009, vol. 37, D603.

    Article  CAS  PubMed  Google Scholar 

  62. Smith, C.A., O’Maille, G., Want, E.J., Qin, C., Trauger, S.A., Brandon, T.R., Custodio, D.E., Abagyan, R., and Siuzdak, G., Ther. Drug Monit., 2005, vol. 27, no. 6, p. 747.

    Article  CAS  PubMed  Google Scholar 

  63. Lau, S.K., Lee, K.C., Curreem, S.O., Chow, W.N., To, K.K., Hung, I.F., Ho, D.T., Sridhar, S., Li, I.W., Ding, V.S., Koo, E.W., Wong, C.F., Tam, S., Lam, C.W., Yuen, K.Y., and Woo, P.C., J. Clin. Microbiol., 2015, vol. 53, no. 12, p. 3750.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Contrepois, K., Jiang, L., and Snyder, M., Mol. Cell Proteomics, 2015, vol. 14, no. 6, p. 1684.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Boelaert, J., Lynen, F., Glorieux, G., Schepers, E., Neirynck, N., and Vanholder, R., Anal. Bioanal. Chem., 2017, vol. 409, no. 8, p. 2201.

    Article  CAS  PubMed  Google Scholar 

  66. Zeng, J., Yin, P., Tan, Y., Dong, L., Hu, C., Huang, Q., Lu, X., Wang, H., and Xu, G., J. Proteome Res., 2014, vol. 13, no. 7, p. 3420.

    Article  CAS  PubMed  Google Scholar 

  67. Tsuruoka, M., Hara, J., Hirayama, A., Sugimoto, M., Soga, T., Shankle, W.R., and Tomita, M., Electrophoresis, 2013, vol. 34, no. 19, p. 2865.

    CAS  PubMed  Google Scholar 

  68. Yang, X., Sun, L., Zhao, A., Hu, X., Qing, Y., Jiang, J., Yang, C., Xu, T., Wang, P., Liu, J., Zhang, J., He, L., Jia, W., and Wan, C., Transl. Psychiatry, 2017, vol. 7, no. 7, p. 1176.

    Article  CAS  Google Scholar 

  69. Shamsipur, M., Naseri, M.T., and Babri, M., J. Pharm. Biomed. Anal., 2013, vol. 81-82, p. 65.

    Article  CAS  PubMed  Google Scholar 

  70. Khalid, T., Aggio, R., White, P., Costello, B.D.L., Persad, R., Al-Kateb, H., Jones, P., Probert, C.S., and Ratcliffe, N., PLoS One, 2015, vol. 10, no. 11, e0143283.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Won, A.J., Kim, S., Kim, Y.G., Kim, K.B., Choi, W.S., Kacew, S., Kim, K.S., Jung, J.H., Lee, B.M., Kim, S., and Kim, H.S., Mol. Biosyst., 2016, vol. 12, no. 1, p. 133.

    Article  CAS  PubMed  Google Scholar 

  72. Pouline, M.P.O., Bruin, S., Weda, H., Knobel, H.H., Schultz, M.J., and Bos, L.D., Int. J. Mol. Sci., 2017, vol. 18, no. 2, p. 449.

    Article  CAS  Google Scholar 

  73. Fu, X., Li, M., Knipp, R.J., Nantz, M.H., and Bousamra, M., Cancer Med., 2014, vol. 3, no. 1, p. 174.

    Article  CAS  PubMed  Google Scholar 

  74. Mikkonen, J.J., Singh, S.P., Herrala, M., Lappalainen, R., Myllymaa, S., and Kullaa, A.M., J. Periodontal. Res., 2016, vol. 51, no. 4, p. 431.

    Article  CAS  PubMed  Google Scholar 

  75. Sugimoto, M., Wong, D.T., Hirayama, A., Soga, T., and Tomita, M., Metabolomics, 2010, vol. 6, no. 1, p. 78.

    Article  CAS  PubMed  Google Scholar 

  76. Calderón-Santiago, M., Priego-Capote, F., Turck, N., Robin, X., Jurado-Gámez, B., Sanchez, J.C., and Luque de Castro, M.D., Anal. Bioanal. Chem., 2015, vol. 407, no. 18, p. 5381.

    Article  CAS  PubMed  Google Scholar 

  77. Galbis-Estrada, C., Martinez-Castillo, S., Morales, J.M., Vivar-Llopis, B., Monleón, D., Díaz-Llopis, M., and Pinazo-Durán, M.D., J. Biomed. Biotechnol., 2014, vol. 2014, 542549.

    Google Scholar 

  78. Chen, L., Zhou, L., Chan, E.C.Y., Neo, J., and Beuerman, R.W., J. Proteome Res., 2011, vol. 10, no. 10, p. 4876.

    Article  CAS  PubMed  Google Scholar 

  79. Li, Z., Du, B., Li, J., Zhang, J., Zheng, X., Jia, H., Xing, A., Sun, Q., Liu, F., and Zhang, Z., Clin. Chim. Acta, 2017, vol. 466, p. 38.

    Article  CAS  PubMed  Google Scholar 

  80. Huang, Q., Tan, Y., Yin, P., Ye, G., Gao, P., Lu, X., Wang, H., and Xu, G., Cancer Res., 2013, vol. 73, no. 16, p. 4992.

    Article  CAS  PubMed  Google Scholar 

  81. Gao, P., Zhou, C., Zhao, L., Zhang, G., and Zhang, Y., J. Pharm. Biomed. Anal., 2016, vol. 118, p. 349.

    Article  CAS  PubMed  Google Scholar 

  82. Vuckovic, D., Anal. Bioanal. Chem., 2012, vol. 403, no. 6, p. 1523.

    Article  CAS  PubMed  Google Scholar 

  83. Bruce, S.J., Tavazzi, I., Parisod, V., Rezzi, S., Kochhar, S., and Guy, P.A., Anal. Chem., 2009, vol. 81, no. 9, p. 3285.

    Article  CAS  PubMed  Google Scholar 

  84. Nagana Gowda, G.A. and Raftery, D., Anal. Chem., 2014, vol. 86, no. 11, p. 5433.

    Article  CAS  PubMed  Google Scholar 

  85. Qiu, Y., Cai, G., Su, M., Chen, T., Zheng, X., Xu, Y., Ni, Y., Zhao, A., Xu, L.X., Cai, S., and Jia, W., J. Proteome Res., 2009, vol. 8, no. 10, p. 4844.

    Article  CAS  PubMed  Google Scholar 

  86. Tiziani, S., Einwas, A.H., Lodi, A., Ludwig, C., Bunce, C.M., Viant, M.R., and Gunther, U.L., Anal. Biochem., 2008, vol. 377, no. 1, p. 16.

    Article  CAS  PubMed  Google Scholar 

  87. Skov, K., Hadrup, N., Smedsgaard, J., and Frandsen, H., J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2015, vols. 978–979, p. 83.

    Article  CAS  Google Scholar 

  88. Fernández-Peralbo, M.A. and Luque de Castro, M.D., TrAC, Trends Anal. Chem., 2011, vol. 41, p. 75.

    Article  CAS  Google Scholar 

  89. Roux, A., Thevenot, E.A., Seguin, F., Olivier, M., and Junot, C., Metabolomics, 2015, vol. 11, no. 5, p. 1095.

    Article  CAS  PubMed  Google Scholar 

  90. Bernini, P., Bertini, I., Luchinat, C., Nincheri, P., Staderini, S., and Turano, P., J. Biomol. NMR, 2011, vol. 49, nos. 3–4, p. 231.

    Article  CAS  PubMed  Google Scholar 

  91. Yang, W., Chen, Y., Xi, C., Zhang, R., Song, Y., Zhan, Q., Bi, X., and Abliz, Z., Anal. Chem., 2013, vol. 85, no. 5, p. 2606.

    Article  CAS  PubMed  Google Scholar 

  92. Fliniaux, O., Gaillard, G., Lion, A., Cailleu, D., Mesnard, F., and Betsou, F., J. Biomol. NMR, 2011, vol. 51, no. 4, p. 457.

    Article  CAS  PubMed  Google Scholar 

  93. Yin, P., Lehmann, R., and Xu, G., Anal. Bioanal. Chem., 2015, vol. 407, no. 17, p. 4879.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. Pérez-Rambla, C., Puchades-Carrasco, L., García-Flores, M., Rubio-Briones, J., López-Guerrero, J.A., and Pineda-Lucena, A., Metabolomics, 2017, vol. 13, no. 5, p. 52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Gonzalez-Dominguez, R., Garcia-Barrera, T., and Gomez-Ariza, J.L., Using direct infusion mass spectrometry for serum metabolomics in alzheimer’s disease, Anal. Bioanal. Chem, 2014, vol. 406, no. 28, p. 7137.

    Article  CAS  PubMed  Google Scholar 

  96. González-Domínguez, R., García-Barrera, T., Vitorica, J., and Gómez-Ariza, J.L., J. Pharm. Biomed. Anal., 2015, vol. 107, p. 378.

    Article  CAS  PubMed  Google Scholar 

  97. Husek, P., Svagera, Z., Hanzlikováa, D., Rimnácová, L., Zahradnícková, H., Opekarová, I., and Simek, P., J. Chromatogr. A, 2016, vol. 1443, p. 211.

    Article  CAS  PubMed  Google Scholar 

  98. Ferreira, A.M.C., Corderoa, B.M., Pozas, Á.P.C., and Pavóna, J.L.P., J. Chromatogr. A, 2016, vol. 1444, p. 32.

    Article  CAS  Google Scholar 

  99. Rimnácová, L., Husek, P., and Simek, P., J. Chromatogr. A, 2014, vol. 1339, p. 154.

    Article  CAS  PubMed  Google Scholar 

  100. Savolainen, O.I., Sandberg, A., and Ross, A.B., J. Proteome Res., 2016, vol. 15, no. 1, p. 259.

    Article  CAS  PubMed  Google Scholar 

  101. Zhong, L., Cheng, F., Lu, X., Duan, Y., and Wang, X., Talanta, 2016, vol. 158, p. 351.

    Article  CAS  PubMed  Google Scholar 

  102. Chervyakov, A.V., Zakharova, M.N., and Pestov, N.B., Ann. Klin. Eksp. Nevrol., 2014, vol. 8, no. 2, p. 51.

    Google Scholar 

  103. Takayama, T., Kuwabara, T., Maeda, T., Noge, I., Kitagawa, Y., Inoue, K., Todoroki, K., Min, J.Z., and Toyooka, T., Anal. Bioanal. Chem., 2015, vol. 407, no. 3, p. 1003.

    Article  CAS  PubMed  Google Scholar 

  104. Kimura, T., Hamase, K., Miyoshi, Y., Yamamoto, R., Yasuda, K., Mita, M., Rakugi, H., Hayashi, T., and Isaka, Y., Sci. Rep., 2016, vol. 6, 26137.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  105. Leuthold, P., Schaeffeler, E., Winter, S., Büttner, F., Hofmann, U., Mürdter, T.E., Rausch, S., Sonntag, D., Wahrheit, J., Fend, F., Hennenlotter, J., Bedke, J., Schwab, M., and Haag, M., J. Proteome Res., 2017, vol. 16, no. 2, p. 933.

    Article  CAS  PubMed  Google Scholar 

  106. Willmann, L., Erbes, T., Krieger, S., Trafkowski, J., Rodamer, M., and Kammerer, B., Anal. Bioanal. Chem., 2015, vol. 407, no. 13, p. 3555.

    Article  CAS  PubMed  Google Scholar 

  107. Yang, Q., Shi, X., Wang, Y., Wang, W., He, H., Lu, X., and Xu, G., J. Sep. Sci., 2010, vol. 33, no. 10, p. 1495.

    Article  CAS  PubMed  Google Scholar 

  108. Wang, S., Zhou, L., Wang, Z., Shi, X., and Xu, G., Anal. Chim. Acta, 2017, vol. 966, p. 34.

    Article  CAS  PubMed  Google Scholar 

  109. Fiehn, O., Garvey, W.T., Newman, J.W., Lok, K.H., Hoppel, C.L., and Adams, S.H., PLoS One, 2010, vol. 5, no. 12, e15234.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Ikeda, A., Nishiumi, S., Shinohara, M., Yoshie, T., Hatano, N., Okuno, T., Bamba, T., Fukusaki, E., Takenawa, T., Azuma, T., and Yoshida, M., Biomed. Chromatogr., 2012, vol. 26, no. 5, p. 548.

    Article  CAS  PubMed  Google Scholar 

  111. Zarate, E., Boyle, V., Rupprecht, U., Green, S., Villas-Boas, S.G., Baker, P., and Pinu, F.R., Metabolites, 2017, vol. 7, no. 1, E1.

    Article  CAS  Google Scholar 

  112. Basanta, M., Jarvis, R.M., Xu, Y., Blackburn, G., Tal-Singer, R., Woodcock, A., Singh, D., Goodacre, R., Thomas, C.L., and Fowler, S.J., Analyst, 2010, vol. 135, no. 2, p. 315.

    Article  CAS  PubMed  Google Scholar 

  113. Basanta, M., Ibrahim, B., Dockry, R., Douce, D., Morris, M., Singh, D., Woodcock, A., and Fowler, S.J., Respir. Res., 2012, vol. 13, no. 1, p. 72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  114. Rudnicka, J., Walczak, M., Kowalkowski, T., Jezierski, T., and Buszewski, B., Sens. Actuators, B, 2014, vol. 202, p. 615.

    Article  CAS  Google Scholar 

  115. Fuchs, P., Loeseken, C., Schubert, J.K., and Miekisch, W., Int. J. Cancer, 2010, vol. 126, no. 11, p. 2663.

    CAS  PubMed  Google Scholar 

  116. Wang, Y., Hu, Y., Wang, D., Yu, K., Wang, L., Zou, Y., Zhao, C., Zhang, X., Wang, P., and Ying, K., Cancer Biomarkers, 2012, vol. 11, no. 4, p. 129.

    Article  CAS  PubMed  Google Scholar 

  117. Monteiro, M., Carvalh, M., Henrique, R., Jerónimo, C., Moreira, N., Lourdes Bastos, M., and Guedes de Pinho, P., Eur. J. Cancer, 2014, vol. 50, no. 11, p. 1993.

    Article  CAS  PubMed  Google Scholar 

  118. Banday, K.M., Pasikanti, K.K., Chan, E.C.Y., Singla, R., Rao, K.V.S., Chauhan, V.S., and Nanda, R.K., Anal. Chem., 2011, vol. 83, no. 14, p. 5526.

    Article  CAS  PubMed  Google Scholar 

  119. Kok, M.G.M., Somsen, G.W., and Jong, G.J., TrAC, Trends Anal. Chem., 2014, vol. 61, p. 223.

    Article  CAS  Google Scholar 

  120. Torii, Y., Kawano, Y., Sato, H., Sasaki, K., Fujimori, T., Kawada, J., Takikawa, O., Lim, C.K., Guillemin, G.J., Ohashi, Y., and Ito, Y., Metabolomics, 2016, vol. 12, no. 5, p. 84.

    Article  CAS  Google Scholar 

  121. Savolainen, O.I., Sandberg, A., and Ross, A.B., J. Proteome Res., 2016, vol. 15, no. 1, p. 259.

    Article  CAS  PubMed  Google Scholar 

  122. Zhou, J. and Yin, Y., Analyst, 2016, vol. 141, no. 23, p. 6362.

    Article  CAS  PubMed  Google Scholar 

  123. Novotny, M.V., Soini, H.A., and Mechref, Y., J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2008, vol. 866, nos. 1–2, p. 26.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to L. A. Kartsova.

Additional information

Translated by V. Makhlyarchuk

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kartsova, L.A., Solov’eva, S.A. Application of Chromatographic and Electrophoretic Techniques to Metabolomic Studies. J Anal Chem 74, 307–315 (2019). https://doi.org/10.1134/S1061934819040051

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1061934819040051

Keywords:

Navigation