Abstract
The aim of this work is to develop cheap, safe, rapid, reliable and reproducible spectrophotometric method for the assay of some antiulcerative drugs namely Omedar, Nadine and Rantag in their pharmaceutical dosages, using methyl red (MR) as a chromogenic reagent. The proposed method is based on the reaction of each of the three drugs with MR at pH 3.0. The optimum analytical variables have been investigated carefully. The maximum absorbance was obtained at 405 nm with absorptivity of 1.35 × 104 L/mol cm. Beer’s law is obeyed in the range of concentration of 0.5–15 μg/mL for ranitidine (active ingredient) content in the studied drugs. The limits of detection and quantification of the drug active ingredient were 0.05 and 0.13 μg/mL, respectively, with a linear regression correlation coefficient of 0.998, and recovery was in the range 99.91–100.48%. Effects of pH, temperature, standing time and MR concentration on the determination of ranitidine hydrochloride of the drugs have been examined. This method is simple and can be used for the determination of ranitidine in the pharmaceutical dosages of antiulcerative drugs.
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Dawson, J., Richards, D.A., Stables, R., Dixon, G.T., and Cockel, R., J. Clin. Pharm. Ther., 1983, vol. 8, no. 1, p.1.
Basavaiaha, K., Nagegowdaa, P., and Ramakrishnab, V., Sci. Asia, 2005, vol. 31, p.207.
McIsaac, R.L., Dixon, J.S., Mills, J.G., and Wood, J.R., Aliment. Pharmacol. Ther., 1991, vol. 5, no. 3, p.227.
Pounder, R.E., Aliment. Pharmacol. Ther., 1991, vol. 5, no. 1, p.227.
Ishida, T., In, Y., and Inoue, M., Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1990, vol. 46, p. 1893.
British Pharmacopoeia, London: British Pharmacopoeia Commission Office, 2010, pp. 1654, 1825, 3059, 2998.
United States Pharmacopoeia, Rockville, MD: The United States Pharmacopeial Convention, 2009, 32th ed., pp. 3273, 3475.
Hassan, E.M. and Belal, F., J. Pharm. Biomed. Anal., 2002, vol. 27, p.31.
Walash, M.I., Belal, F., Ibrahim, F., Hefnawy, M., and Eid, M., J. AOAC Int., 2002, vol. 85, p. 1316.
Rustum, A.M., J. Liq. Chromatogr., 1988, vol. 11, p. 2315.
Campanero, M.A., Lopez, O.A., Garcia, Q.E., Sadaba, B., and Maza, A.D., Chromatographia, 1998, vol. 47, p.391.
Wong, C.F., Peh, K.K., and Yuen, K.H., J. Chromatogr. B: Biomed. Sci. Appl., 1998, vol. 718, p.205.
Dasgupta, V., Drug Dev. Ind. Pharm., 1988, vol. 14, p. 1647.
Farthing, D., Brouer, K.L., Fakhry, R.I., and Sica, D., J. Chromatogr. B: Biomed. Sci. Appl., 1997, vol. 688, p.350.
Haque, T., Talukder, M.M., Laila, S., and Fatema, K., Pak. J. Pharm. Sci., 2010, vol. 23, no. 4, p.379.
Carey, P.F., Martin, L.E., and Owen, P.E., J. Chromatogr. B: Biomed. Sci. Appl., 1981, vol. 225, p.161.
Perez, C., Juarez Olguin, H., Flores Perez, J., Toledo Lopez, A., Lares Asseff, I., Flores Perez, C., and Alvarez Garcia, C., J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2003, vol. 795, p.141.
Nikolic, K., Stankovic, B., and Bogavac, M., Pharmazie, 1995, vol. 50, p.301.
Shou-Mei, W.U., Yu, H.H., Hsin, L.W., Su, H.C., and Hwang, S.K., Electrophoresis, 2001, vol. 22, p. 2717.
Kelly, M.A., Altria, K.D., Grace, C., and Clark, B.J., J. Chromatogr. A, 1998, vol. 798, p.297.
Gao, Y., Tian, Y., Sun, X., Yin, X.-B., Xiang, Q., Ma, G., and Wang, E., J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2006, vol. 832, p.236.
Lopez, C.E., Vinas, P., Campillo, N., and Hernandez, M.C., Analyst, 1996, vol. 121, p. 1043.
Khadiga, M.K., Azza, M.A., Maha, A.H., and Laila, A.F., J. AOAC Int., 2002, vol. 85, p. 1015.
Parviz, N., Mohammad, R.G., and Parandis, D., J. Pharmacol. Toxicol., 2007, vol. 15, p.289.
Yousry, M., Badawy, S.S., and Mutair, A.A., Anal. Sci., 2005, vol. 21, p. 1443.
Saad, S.M.H., Wagiha, H.M., and Abdel Hameed, M.O., Anal. Chim. Acta, 1996, vol. 332, p.39.
Richter, P., Toral, M.I., and Munoz-Vargas, F., Analyst, 1994, vol. 119, p. 1371.
Rosa, S.S., Barata, P.A., Martins, J.M., and Menezes, J.C., Talanta, 2008, vol. 75, p.725.
Basavaiah, K. and Nage, G., Ind. Pharm., 2004, vol. 3, p.60.
Basavaiah, K., Nagegowda, P., and Ramakrishna, V., Sci. Asia, 2005, vol. 31, p.207.
Moldovan, Z. and Aboul-Enein, H.Y., J. Iran. Chem. Soc., 2012, vol. 9, no. 6, p.851.
Emmanuel, J. and Haldankar, S.D., Indian Drugs, 1989, vol. 26, p.249.
Amin, S., Ahmed, I.S., Dessouki, H.A., and Gouda, E.A.B., Spectrochim. Acta, Part A, 2003, vol. 59, p.695.
Rao, E.V., Rao, J.J., Murthy, S.S.N., and Rao, G.R., Indian J. Pharm. Sci., 1987, vol. 49, p.143.
Walash, M., Sharaf-El Din, M., Metwalli, M.E., and RedaShabana, M., Arch. Pharm. Res., 2004, vol. 27, p.720.
Ozsoy, Y. and Guvner, B., Acta Pharm. Turc., 1987, vol. 29, p.13.
Sastry, C.S.P., Rao, S.G., Rao, J.S., and Naidu, P.Y., Anal. Lett., 1997, vol. 30, p. 2377.
Al-Ghannam, S. and Belal, F., J. AOAC Int., 2002, vol. 85, p. 1003.
Basavaiah, K. and Somashekar, B.C., J. Iran. Chem. Soc., 2007, vol. 4, p.78.
Basavaiah, K. and Somashekar, B.C., Ecletica. Quim., 2007, vol. 32, p.19.
Job, P., Ann. Chim. Appl., 1928, vol. 9, p.113.
ICH Guideline, International conference on harmonization of technical requirements for registration of pharmaceuticals for human use, Validation of Analytical Procedures: Text and Methodology, London, Q2 (R1), 2005.
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Elgailani, I.E.H., Alamry, M.A. Spectrophotometric Determination of Some Antiulcerative Drugs in Pharmaceutical Dosages. J Anal Chem 73, 679–684 (2018). https://doi.org/10.1134/S1061934818070079
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DOI: https://doi.org/10.1134/S1061934818070079