Abstract
The possibility of using hyper-crosslinked polystyrene for the dynamic sorption preconcentration (solid-phase extraction) of tetracycline antibiotics (tetracycline, oxytetracycline, chlortetracycline, and doxycycline) from aqueous solutions has been studied. The conditions of the preconcentration of tetracyclines on a microcolumn filled with hyper-crosslinked polystyrene have been optimized. The compounds were desorbed with 2 mL of an acetonitrile-methanol mixture and determined in the eluate by reversed-phase HPLC with an amperometric detector. With preconcentration the limits of detection for tetracyclines were reduced by 90–100 times. The limits of detection were 0.6 ng/mL for oxytetracycline and tetracycline, 1 ng/mL for chlortetracycline, and 2 ng/mL for doxycycline. The method has been used for the analysis of model mixture based on river water.
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Original Russian Text © A.Yu. Udalova, S.G. Dmitrienko, S.V. Natchuk, V.V. Apyari, Yu.A. Zolotov, 2015, published in Zhurnal Analiticheskoi Khimii, 2015, Vol. 70, No. 3, pp. 273–278.
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Udalova, A.Y., Dmitrienko, S.G., Natchuk, S.V. et al. Preconcentration of tetracycline antibiotics on a hyper-crosslinked polystyrene and their determination in waters by high-performance liquid chromatography. J Anal Chem 70, 292–297 (2015). https://doi.org/10.1134/S1061934815030211
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DOI: https://doi.org/10.1134/S1061934815030211