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Genome-Wide Selection Signal Analysis of Australian Boer Goat by Insertion/Deletion Variants

  • ANIMAL GENETICS
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Abstract

Selection in breeds for commercial goat is needed for production efficiency, growth trait alteration, and improved livestock quality. Boer goat is famous for its stable production performance, fast growth rate, and high meat production. Detecting selective signatures in its genome can elucidate selection mechanisms for its economic and adaptive traits. In this study, 1 122 858 InDels were identified based on the whole genomes of 46 Australian Boer goats and 81 indigenous goats. FST was used to identify the candidate selection signatures in 127 goats. A total of 11 229 InDels were obtained from the top 1% of all InDels, and 1239 candidate genes were annotated. A total of 1193 and 476 candidate genes were involved in 4726 GO terms and 299 KEGG pathways, respectively. Many genes were related to muscle development (MEF2C, MAPK14, TMOD1, etc.), reproduction (SRD5A1, FBXW11, DMRT1, etc.), immunity (CD200, SGK1, IL17RB, etc.) and metabolism (INSR, STXBP3, H6PD, etc.). The results provide novel and important insights into the genetic basis of selection in Boer goat and may be useful for goat molecular breeding.

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Funding

This work was supported by Chongqing Natural Science Foundation (cstc2021jcyj-msxmX0013, National Natural Science Foundation of China (no. 31172195).

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  1. College of Animal Science and Technology, Southwest University, 400715, Chongqing, China

    Y. Yuan, B. Yang, Y. He, W. Zhang & G. E

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Statement on the welfare of animals. The experiment was carried out in strict accordance with the guidelines of the International Cooperation Committee of Animal Welfare on the care and use of experimental animals.

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Genomes (>10 × depth) of 46 Australian Boer goats (case group) were obtained from our published parallel projects (PRJNA671542).

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Yuan, Y., Yang, B., He, Y. et al. Genome-Wide Selection Signal Analysis of Australian Boer Goat by Insertion/Deletion Variants. Russ J Genet 58, 1504–1512 (2022). https://doi.org/10.1134/S1022795422120158

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