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Mutations in RAS/BRAF genes in rectal tumors: From adenomas to early carcinomas

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Abstract

The frequency and spectrum of mutations in RAS/BRAF genes were studied in rectal adenomas, carcinomas in situ, and adenocarcinomas. It is shown that the frequency of KRAS mutations decreases from adenoma to adenocarcinoma; most adenomas and carcinomas in situ are heterogeneous and consist of several subclones. Possible models of colorectal cancer pathogenesis are discussed.

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Authors and Affiliations

  1. Ryzhikh State Scientific Center of Coloproctology, Moscow, 123423, Russia

    Yu. A. Shelygin, O. A. Maynovskaya, E. G. Rybakov, V. P. Shubin, S. V. Chernyshov, S. A. Frolov, V. N. Kashnikov & N. I. Pospekhova

Authors
  1. Yu. A. Shelygin
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  2. O. A. Maynovskaya
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  3. E. G. Rybakov
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  4. V. P. Shubin
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  5. S. V. Chernyshov
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  6. S. A. Frolov
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  7. V. N. Kashnikov
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  8. N. I. Pospekhova
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Corresponding author

Correspondence to N. I. Pospekhova.

Additional information

Original Russian Text © Yu.A. Shelygin, O.A. Maynovskaya, E.G. Rybakov, V.P. Shubin, S.V. Chernyshov, S.A. Frolov, V.N. Kashnikov, N.I. Pospekhova, 2017, published in Genetika, 2017, Vol. 53, No. 10, pp. 1218–1223.

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Shelygin, Y.A., Maynovskaya, O.A., Rybakov, E.G. et al. Mutations in RAS/BRAF genes in rectal tumors: From adenomas to early carcinomas. Russ J Genet 53, 1146–1151 (2017). https://doi.org/10.1134/S1022795417080075

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  • DOI: https://doi.org/10.1134/S1022795417080075

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