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Methylation in the regulation of the expression of chromosome 3 and microRNA genes in clear-cell renal cell carcinomas

  • Reviews and Theoretical Articles
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Abstract

The methylation of CpG islands in promoter regions, together with the interaction of miRNAs with the mRNAs of their target genes on the posttranscriptional level, are complex epigenetic mechanisms that perform the delicate and dynamic regulation of genes and signal transduction pathways in the cell. This review summarizes the results obtained by the authors, as well as the literature data, on the roles of methylation in regulating the protein-coding genes of chromosome 3 and a number of miRNA genes in clear-cell renal cell carcinomas. The results are based on the use of genomic NotI-microarrays (which allow the identification of both methylation and deletions in genes containing CpG islands) and on some other approaches. The application of NotI-microarray technology to the analysis of the chromosome-3 short arm, a region of frequent deletions in tumors, gave us the opportunity to identify many novel genes associated with kidney cancer pathogenesis. The relationship between alterations in the expression levels and methylation of chromosome 3 genes, kidney cancer progression, and metastasis was shown. New microRNAs involved in kidney cancer pathogenesis were identified as well. The functions of microRNA genes methylated in kidney cancer were discussed.

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Abbreviations

miRNA:

microRNA

NotI-MA:

NotI-microarrays

3p:

chromosome-3 short arm

CCRCC:

clear-cell renal cell carcinoma

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Authors and Affiliations

  1. Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, 125315, Russia

    E. A. Braga, V. I. Loginov, I. V. Pronina & A. A. Kubatiev

  2. Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, 115478, Russia

    E. A. Braga, V. I. Loginov & I. V. Pronina

  3. Federal Research Clinical Center of the Federal Medical and Biological Agency of Russia, Moscow, 115682, Russia

    D. S. Khodyrev

  4. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia

    V. N. Senchenko & A. A. Dmitriev

  5. Blokhin Cancer Research Center, Moscow, 115478, Russia

    N. E. Kushlinskii

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  1. E. A. Braga
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  2. D. S. Khodyrev
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  3. V. I. Loginov
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Correspondence to E. A. Braga.

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Original Russian Text © E.A. Braga, D.S. Khodyrev, V.I. Loginov, I.V. Pronina, V.N. Senchenko, A.A. Dmitriev, A.A. Kubatiev, N.E. Kushlinskii, 2015, published in Genetika, 2015, Vol. 51, No. 6, pp. 668–684.

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Braga, E.A., Khodyrev, D.S., Loginov, V.I. et al. Methylation in the regulation of the expression of chromosome 3 and microRNA genes in clear-cell renal cell carcinomas. Russ J Genet 51, 566–581 (2015). https://doi.org/10.1134/S1022795415050026

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