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Construction and Functional Properties of Multifunctional Chitosan Hydrogel

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Abstract—

Hydrogel is a kind of new functional polymer material with application value and economic benefit. It has wide application in biomedical field because of its good biocompatibility and hydrophilicity.In this work, chitosan hydrogel was prepared by free radical graft copolymerization using natural biodegradable polymer chitosan as the carrier, temperature sensitive N-isopropylacrylamide (NIPAm) and pH sensitive 2‑acrylamido-2-methylpropane (AMPS) as monomers. The adsorption and drug release properties of chitosan hydrogel are discussed emphatically.The adsorption performance of chitosan hydrogel on copper ions showed that the temperature and the concentration of copper ions had influence on the adsorption. When the concentration of copper ions was 800 mg/L at 25°C, the equilibrium adsorption capacity was 225.8 mg/g, quasi-second order kinetic equation was suitable for describing the adsorption process. With the methylene blue as the drug model, the controlled release results showed that the temperature and the initial drug dosage had great effect on controlled release performance, and the cumulative release rate of 48 h was about 70%, which could achieve sustained release and controlled release to a certain extent.The experimental results also showed that the chitosan hydrogel can be completely degraded for about 20 days with excellent degradation performance. In conclusion, chitosan hydrogel has broad application prospects in drug controlled release, tissue engineering, environmental engineering and so on.

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Funding

This work was supported by grants from the Scientific Research Program Funded by Shaanxi Provincial Science and Technology Department (no. 2020GY-322), Xi’an Weiyang District Science and Technology Plan Project (no. 201931), Training Program of Innovation and Entrepreneurship for Undergraduates (no. 2018078), the Scientific Research Program Funded by Shaanxi Provincial Science and Technology Department (no. 2020GY-321) and the project of Young Talent fund of University Association for Science and Technology in Shaanxi (no. 20180606).

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Authors and Affiliations

  1. Department of Pharmacy and Shaanxi Key Laboratory of Brain Disorders and Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Xi’an Medical University, 710021, Xi’an, China

    Fei Liang

  2. School of Environmental and Chemical Engineering, Xi’an Polytechnic University, 710048, Xi’an, China

    Jing Zhao & Chunyu Deng

Authors
  1. Fei Liang
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  2. Jing Zhao
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  3. Chunyu Deng
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Correspondence to Fei Liang.

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Fei Liang, Zhao, J. & Deng, C. Construction and Functional Properties of Multifunctional Chitosan Hydrogel. Polym. Sci. Ser. A 62, 494–501 (2020). https://doi.org/10.1134/S0965545X20050120

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  • DOI: https://doi.org/10.1134/S0965545X20050120

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