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On the Stability of Aqueous Nanodispersions of Polyelectrolyte Complexes Based on Chitosan and N-Succinyl-Chitosan

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Abstract

From the point of view of aggregative stability, aqueous dispersions of particles of polyelectrolyte complexes based on chitosan hydrochloride and sodium salt of N-succinyl-chitosan were obtained and characterized. It is shown that, in the entire range of experimental conditions considered, these polyelectrolytes form an aggregately unstable disperse system. At the same time, the relative aggregative stability of the systems (the time before the formation of a precipitate of the polyelectrolyte complex) increases with an increase in the molecular weights of the polymers, with an increase in the molar ratio of the components, and with an increase in the concentration of polymers in the solution and reaches 30 days. The average particle size in the region of the relative aggregative stability of dispersed systems is 100–380 nm, which is promising for their use as lysed drug carriers for their targeted transport in the body.

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Funding

The work was performed in the Institute of Chemistry UFRC RAS within the State task for 2017–2019 (AAAA-A17-117011910026-3).

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences, 450054, Ufa, Russia

    S. V. Kolesov, M. S. Gurina & R. Kh. Mudarisova

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  1. S. V. Kolesov
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  2. M. S. Gurina
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  3. R. Kh. Mudarisova
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Correspondence to R. Kh. Mudarisova.

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Kolesov, S.V., Gurina, M.S. & Mudarisova, R.K. On the Stability of Aqueous Nanodispersions of Polyelectrolyte Complexes Based on Chitosan and N-Succinyl-Chitosan. Polym. Sci. Ser. A 61, 253–259 (2019). https://doi.org/10.1134/S0965545X19030076

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