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Influence of Chitosan Molecular Weight and Poly(ethylene oxide): Chitosan Proportion on Fabrication of Chitosan Based Electrospun Nanofibers

  • Natural Polymers
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Abstract

Fabrication of electrospun chitosan nanofibers is still a controversial issue in publications. Although regarding the lots of reports, mixtures of chitosan with a hydrophilic synthetic polymer such as polyethylene oxide (PEO) have been electrospun successfully, abundance of partly contradictory protocols in which one variable has been surveyed in each study is unfortunately baffling. In the present study, influence of three considerable parameters including the average molecular weight of chitosan, chitosan solution concentration and the mass ratio of polyethylene oxide to chitosan at the mixtures on electrospinning possibility as well as the quality of as-spun fibers is investigated. Eventually, the necessities for obtaining the best results are introduced followed by further analysis of optimized nanofibers using atomic force microscopy. According to our results, the blend solutions prepared from the low molecular weight (LMW) chitosan and PEO are efficient for reproducible production of bead-free electrospun nanofibers even in low proportion of polyethylene oxide.

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Authors and Affiliations

  1. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

    Alireza Naderi Sohi, Hossein Naderi-Manesh & Mohammad Delbari

  2. Department of Hematology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran

    Masoud Soleimani

  3. Stem Cell Technology Research Center, Tehran, Iran

    Samaneh Mirzaei & Masumeh Dodel

Authors
  1. Alireza Naderi Sohi
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  2. Hossein Naderi-Manesh
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  3. Masoud Soleimani
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  4. Samaneh Mirzaei
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  5. Mohammad Delbari
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  6. Masumeh Dodel
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Correspondence to Hossein Naderi-Manesh.

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Sohi, A.N., Naderi-Manesh, H., Soleimani, M. et al. Influence of Chitosan Molecular Weight and Poly(ethylene oxide): Chitosan Proportion on Fabrication of Chitosan Based Electrospun Nanofibers. Polym. Sci. Ser. A 60, 471–482 (2018). https://doi.org/10.1134/S0965545X18040077

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  • DOI: https://doi.org/10.1134/S0965545X18040077

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