Abstract
Both, gel forming dietary fiber psyllium and antibiotic drug ciprofloxacin, have pharmacological importance in case of gastrointestinal tract problems. Hence, in the present work, an attempt has been made to design the ciprofloxacin loaded psyllium cross-linked poly(hydroxyethylmethacrylate-co-acrylamide) based sterile hydrogels for drug delivery application in gastrointestinal tract problems diverticulitis which occur due to constipation and microbial infestation. These polymers have been characterized by SEM, cryo-SEM, EDAX, FTIR, TGA/DTA/DTG, XRD. The swelling of the hydrogels and release dynamics of drug from the hydrogels have been studied for the evaluation of the swelling and drug release mechanism respectively. The release of the drug from the hydrogels occurred through non-Fickian diffusion mechanism in slow manner. Overall, the ciprofloxacin loaded psyllium based drug delivery system may act with enhanced potential to cure the diverticulitis.
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H. Tian, Z. Tang, X. Zhuang, X. Chen, and X. Jing, Prog. Polym. Sci. 37, 237 (2012).
P. Sriamornsak and R. A. Kennedy, Carbohydr. Polym. 79 (1), 219 (2010).
T. R. Bhardwaj, M. Kanwar, R. Lal, and A. Gupta, Drug Dev. Ind. Pharm. 26, 1025 (2000).
W. He and R. Benson, “Polymeric Biomaterials,” in Handbook of Biopolymers and Biodegradable Plastics, Ed. by S. Ebnesajjad (Elsevier Inc., US, 2013), p. 87–107.
A. S. Hoffman, Adv. Drug Delivery Rev. 64, 18 (2012).
T. Coviello, P. Matricardi, C. Marianecci, and F. Alhaique, J. Controlled Release 119, 5 (2007).
K. Mostafa and M.S. Morsy, Polym. Int. 53, 885 (2004).
E. Karadag, D. Saraydin, and O. Güven, Macromol. Mater. Eng. 286, 34 (2001).
A. Safrany, B. Beiler, and A. Vincze, Radiat. Phys. Chem. 79, 462 (2010).
J. M. Rosiak, P. Ulanski, L. A. Pajewski, F. Yoshii, and K. Makuuchi, Radiat. Phys. Chem. 46, 161, (1995).
M. M. Nasef and O. Guven, Prog. Polym. Sci. 37, 1597 (2012).
M. Prabaharan, Int. J. Biol. Macromol. 49, 117 (2011).
M.S. Izydorczyk and C.G. Carbohydr. Polym. 28, 33 (1995).
B. Singh, Int. J. Pharma. 334, 1 (2007).
V. Freiche, D. Houston, H. Weese, M. Evason, G. Deswarte, G. Ettinger, Y. Soulard, V. Biourge, and A. J. German, J. Feline Med. Surg. 13, 903 (2011).
J. W. McRorie, B. P. Daggy, J. G. Morel, P. S. Diersing, P. B. Miner, and M. Robinson, Aliment. Pharmacol. Ther. 12, 491 (1998).
F. Fernandez-Banares, Best Pract. Res., Clinic. Gastroenterol. 20, 575 (2006).
W. G. Thompson, G. F. Longstreth, D. A. Drossman, K. W. Heaton, E. J. Irvine, and S. A. Müller-Lissner, Gut 45 (2), II43 (1999).
J. Stevens, P. J. VanSoest, J. B. Robertson, and D. A. Levitsky, J. Am. Diet. Assoc. 88, 323 (1988).
H. J. Naghash and O. Okay, J. Appl. Polym. Sci. 60, 971 (1996).
T. H. Yang, Recent Pat. Mater. Sci. 1, 29 (2008).
A. Kidane, J. M. Szabocsik, and K. Park, Biomaterials 19, 2051 (1998).
H. R. Oxley, P. H. Corkhill, J. H. Fitton, and B. J. Tighe, Biomaterials 14, 1064 (1993).
R. Mohapatra, D. Ray, A. K. Swain, T. K. Pal, and P. K. Sahoo, J. Appl. Polym. Sci. 108, 380 (2007).
B. Mirzaagha, E. Ladan, and R. Lida, J. Polym. Res. 14, 207 (2007).
J. P. Montheard, M. Chatzopoulos, and D. Chappard, J. Macromol. Sci., Part C: Polym. Rev. 32, 1 (1992).
Biomedical Applications of Hydrogels Handbook, Ed. by R. M. Ottenbrite, K. Park, and T. Okano (Springer, New York, 2010).
S. L. Tomic, M. M. Micic, J. M. Filipovic, and E. H. Suljovrujic, Radiat. Phys. Chem. 76, 1390 (2007).
J. Wang and W. Wu, Eur. Polym. J. 41, 1143 (2005).
D. M. Garcia, J. L. Escobar, Y. Noa, N. Bada, E. Hernaez, and I. Katime, Eur. Polym. J. 40, 1683 (2004).
A. Avila, K. Bierbrauer, G. Pucci, M. Lopez-González, and M. Strumia, J. Food Eng. 109, 752 (2012).
Y. K. Bhardwaj, S. Sabharwal, and A. B. Majali, J. Polym. Mater. 17, 239 (2000).
Y. K. Bhardwaj, S. Sabharwal, and A. B. Majali, J. Polym. Mater. 18, 37 (2001).
N. C. Dafader, M. N. Adnan, M. E. Haque, D. Huq, and F. Akhtar, Afr. J. Pure Appl. Chem. 5, 111 (2011).
Pharmacopoeia of India, 3rd ed. (Controller of Publications, Delhi, 1985), Vol. II, Appendex-7, A-142.
B. Singh and N. Sharma, Biomacromolecules 10, 2515 (2009).
T. Alfrey, E. F. Gurnee, and W. G. Lloyd, J. Polym. Sci., Part C: Polym. Symp. 12, 249 (1966).
N. A. Peppas and R. W. Korsmeyer, “Dynamically Swelling Hydrogels,” in Controlled Release Applications, In Hydrogels in Medicines and Pharmacy, Vol. III. Properties and Applications, Ed. by N. A. Peppas (CRC Press Inc., Boca Raton, FL, 1987), p. 118.
P. L. Ritger and N. A. Peppas, J. Controlled Release 5, 23 (1987).
P. L. Ritger and N. A. Peppas, J. Controlled Release 5, 37 (1987).
A. F. Zhu, J. M. Dai, J. Xie, G. Li, and J. M. Jiang, J. Fiber Bioeng. Inf. 3, 231 (2011).
M. J. Dykstra, Biological Electron Microscopy: Theory, Techniques, and Troubleshooting (Plenum Press, New York, 2002).
J. Zhang and N. A. Peppas, J. Biomater. Sci., Polym. Ed. 13, 511 (2002).
A. Farahnaky, H. Askari, M. Majzoobi, and G. Mesbahi, J. Food Eng. 100, 294 (2010).
S. Yarimkaya and H. Basan, J. Macromol. Sci., Part A: Pure Appl. Chem. 44, 939 (2007).
L. Ferreira, M.M. Vidal, and M.H. Gil, Int. J. Pharmacol. 194, 169 (2000).
Y. Zhou, D. Yang, X. Gao, X. Chen, Q. Xu, F. Lu, and J. Nie, Carbohydr. Polym. 75, 293 (2009).
M. F. Abou Taleb, S. E. Abdel-Aal, N. A. El-Kelesh, and E-S. A. Hegazy, Eur. Polym. J. 43, 468 (2007).
H. N. Oztop, A. Y. Oztop, Y. Isikver, and D. Saraydin, Process Biochem. 37, 651 (2002).
H. A. Abd El-Rehim and D. A. Dia, Carbohydr. Polym. 87, 1905 (2012).
H. He, J. Guan, and J. L. Lee, J. Controlled Release 110, 339, (2006).
M. Jaiswal and V. Koul, J. Biomater. Appl. 27, 848 (2013).
M. Micic, D. Stamenic, and E. Suljovrujic, Radiat. Phys. Chem. 81, 1451, (2012).
J. F. Lutz, K. Weichenhan, O. Akdemir, and A. Hoth, Macromolecules 40, 2503, (2007).
W.-F. Lee and R.-J. Wu, J. Appl. Polym. Sci. 81, 1360 (2001).
G. Mclauchlan, G. N. Fullarton, G. P. Crean, K. E. L. Mccoll, Gut 30, 573 (1989)
B. N. Singh, Recent Pat. Drug Delivery Formulation 1, 53 (2007).
V. V. Krongauz and C. P. Chawla, in Proceeding of Rad. Tech. Europe, Basel, Switzerland, 2001 (Basel, Switzerland, 2001), p. 245.
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Singh, B., Bala, R. Radiation formation of psyllium cross-linked poly(hydroxyethylmethacrylate)-co-poly(acrylamide) based sterile hydrogels for drug delivery applications. Polym. Sci. Ser. A 59, 363–375 (2017). https://doi.org/10.1134/S0965545X17030166
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DOI: https://doi.org/10.1134/S0965545X17030166