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Features of the Influence of the Autonomic Nervous System on the Regulatory and Metabolic Parameters of Lymphocytes in Healthy Children and Children with Special Health Needs

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Abstract

The aim of the study was to analyze the content of biogenic monoamines (catecholamins and serotonin) and metabolic parameters (activities of succinate dehydrogenase and acid phosphatase) of lymphocytes in normal children and in children with special health needs, depending on the type of autonomic regulation. The survey involved 168 children of primary school age, of these, 114 relatively healthy children and 54 children with intellectual disabilities (mild (F70) and moderate (F71) degree of mental retardation). The groups were comparable in terms of gender and age. In both studied groups, an increase in the parameters of succinate dehydrogenase and catecholamines from vagotonic to hypersympathicotonic types of the initial vegetative tone was recorded. Also, in the group of children with special health needs, a decrease in the activity of acid phosphatase was found as the activity of the sympathetic division of the autonomic nervous system (ANS) increased. In general, in healthy children, against the background of the prevailing eutonic type of autonomic regulation, the optimal regulatory and metabolic parameters of the cell are fixed, which determines sufficient adaptive responses in this group. In the group of children with disabilities, the dominant activity of the sympathetic division of the autonomic nervous system manifests itself at the cellular level as hypercatecholaminemia, reduced levels of serotonin, and acid phosphatase activity.

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Funding

The study was carried out at the expense of funds allocated for the implementation of the state task.

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Authors and Affiliations

  1. Scientific Research Institute for Medical Problems of the North, Russian Academy of Sciences, Krasnoyarsk, Russia

    O. V. Smirnova, E. S. Ovcharenko, E. V. Kasparov & V. V. Fefelova

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  1. O. V. Smirnova
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  2. E. S. Ovcharenko
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  3. E. V. Kasparov
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  4. V. V. Fefelova
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Correspondence to O. V. Smirnova.

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COMPLIANCE WITH ETHICAL STANDARDS

All studies were carried out in accordance with the principles of biomedical ethics formulated in the Declaration of Helsinki of 1964 and its subsequent updates, and approved by the local bioethical committee of the Scientific Research Committee of Medical Problems of the North (Krasnoyarsk).

CONFLICT OF INTEREST

The authors declare the absence of any obvious and potential conflict of interest related to the publication of this article.

INFORMED CONSENT

Parents or legal guardians of the study children signed a voluntary written informed consent after explaining the potential risks and benefits, as well as the nature of the upcoming study.

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Smirnova, O.V., Ovcharenko, E.S., Kasparov, E.V. et al. Features of the Influence of the Autonomic Nervous System on the Regulatory and Metabolic Parameters of Lymphocytes in Healthy Children and Children with Special Health Needs. Hum Physiol 49, 147–154 (2023). https://doi.org/10.1134/S0362119722600357

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  • DOI: https://doi.org/10.1134/S0362119722600357

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