Skip to main content
SpringerLink
Log in

Comparative Analysis of Microcirculatory Reactions to Hypoxic Effects in Male and Female Subjects

  • Published:
Human Physiology Aims and scope Submit manuscript

Abstract

In this study, we conducted a comparative analysis of the responses to hypoxia of microcirculation (MCR) parameters of the temporal areas of the head in male and female subjects. The study was conducted in 20 healthy volunteers aged 18–19 (10 male and 10 female). The state of short-term hypoxia was induced using a ReOxy Cardio normobaric device (S.A. Aimediq, Luxembourg). Synchronous measurements of MCR parameters of symmetrical temporal regions of the head in the basal state and immediately after short-term hypoxic exposure were carried out by laser Doppler flowmetry. Statistical characteristics of perfusion of both sides of the measurement and correlation characteristics of the relationships between changes in the MCR parameters of the symmetric sides of the observation were evaluated. The results show sex differences in reactions to hypoxic effects. In 80% of men, hypoxia led to an increase in left perfusion; in 20%, to a decrease. In women, the opposite pattern was observed: in 10%, perfusion on the left increased, and in 90%, it decreased. The results of the research revealed the features of left–right asymmetry in the regulation of MCR parameters of the temporal regions of the heads of males and females. The physiological mechanisms underlying the differences in the regulation of MCR parameters of the symmetrical regions of the male and female brain require further study.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

REFERENCES

  1. Glazachev, O.S. and Dudnik, E.N., Microcirculatory reactivity features in apparently healthy individuals during acute moderate hypoxia and hyperoxia modeling, Hum. Physiol., 2013, vol. 39, no. 4, p. 400.

    Article  CAS  Google Scholar 

  2. Bobyleva, O.V. and Glazachev, O.S., Microcirculation characteristics in apparently healthy subjects during acute hypoxia and intermittent hypoxic training, Hum. Physiol., 2008, vol. 34, no. 6, p. 735.

    Article  Google Scholar 

  3. Krivoshekov, S.G., Balioz, N.V., Nekipelova, N.V., and Kapilevich, L.V., Age, gender, and individually-typological features of reaction to sharp hypoxic influence, Hum. Physiol., 2014, vol. 40, no. 6, p. 613.

    Article  Google Scholar 

  4. Mikhailichenko, L.A., Microcirculation indicators of paired organs and tissues of experimental healthy animals, Reg. Krovoobrashch. Mikrotsirk., 2007, vol. 6, no. 1, p. 164.

    Google Scholar 

  5. Mikhailichenko, L.A., Endothelial component in the mechanisms of regulation of vascular tone of paired formations according to laser Doppler flowmetry, Reg. Krovoobrashch. Mikrotsirk., 2008, vol. 28, no. 4, p. 71.

    Google Scholar 

  6. Mezentseva, L.V. and Pertsov, S.S., Synchronous changes in microcirculation parameters of the upper limbs in asymmetric physical loads, Hum. Physiol., 2020, vol. 46, no. 6, p. 671.

    Article  Google Scholar 

  7. Mezentseva, L.V., Dudnik, E.N., Nikenina, E.V., et al., Analysis of changes in microcirculation parameters of symmetrical areas of the human head under conditions of hypoxic influences, Bull. Exp. Biol. Med., 2021, vol. 171, no. 6, p. 691.

    Article  CAS  Google Scholar 

  8. Amunts, V.V., Antyukhov, A.D., Bogolepova, I.N., and Sveshnikov, A.V., Comparative data of neurons of two nuclei of the thalamus in men and women, Asimmetriya, 2012, vol. 6, no. 1, p. 17.

    Google Scholar 

  9. Ingalhalikar, M., Smith, A., Parker, D., et al., Sex differences in the structural connectome of the human brain, Proc. Natl. Acad. Sci. U.S.A., 2014, vol. 111, no. 2, p. 823.

    Article  CAS  Google Scholar 

  10. Reber, J. and Tranel, D., Sex differences in the functional lateralization of emotion and decision making in the human brain, J. Neurosci. Res., 2017, vol. 95, nos. 1–2, p. 270.

    Article  CAS  Google Scholar 

  11. Pallayova, M., Brandeburova, A., and Tokarova, D., Update on sexual dimorphism in brain structure-function interrelationships: a literature review, Appl. Psychophysiol. Biofeedback, 2019, vol. 44, no. 4, p. 271.

    Article  Google Scholar 

  12. Benedicic, M., Bernjak, A., Stefanovska, A., and Bosnjak, R., Continuous wavelet transform of laser-Doppler signals from facial microcirculation reveals vasomotion asymmetry, Microvasc. Res., 2007, vol. 74, no. 1, p. 45.

    Article  Google Scholar 

  13. Huxley, V.H. and Kemp, S.S., Sex-specific characteristics of the microcirculation, Adv. Exp. Med. Biol., 2018, vol. 1065, p. 307.

    Article  Google Scholar 

  14. Kobayashi, T., Shiba, T., Kinoshita, A., et al., The influences of gender and aging on optic nerve head microcirculation in healthy adults, Sci. Rep., 2019, vol. 30, no. 9, p. 15636.

    Article  Google Scholar 

  15. Panazzolo, D.G., Silva, L.H., Cyrino, F.Z., et al., Gender differences in microcirculation: observation using the hamster cheek pouch, Clinics (Sao Paulo), 2013, vol. 68, no. 12, p. 1537.

    Article  Google Scholar 

  16. Gonzales, R.J., Bryant, J.M., Naik, J.S., et al., Gender differences in mesenteric vasoconstrictor reactivity following chronic hypoxia, Microcirculation, 2008, vol. 15, no. 6, p. 473.

    Article  CAS  Google Scholar 

  17. Mortola, J.P. and Saiki, C., Ventilatory response to hypoxia in rats: gender differences, Respir. Physiol., 1996, vol. 106, no. 1, p. 21.

    Article  CAS  Google Scholar 

  18. Marcouiller, F., Jochmans-Lemoine, A., Ganouna-Cohen, G., et al., Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice, Am. J. Physiol.: Endocrinol. Metab., 2021, vol. 320, no. 2, p. 316.

    Google Scholar 

Download references

Funding

Anokhin Research Institute of normal physiology, Moscow, Russia Institute of Clinical Medicine of the Sechenov First Moscow State Medical University (Sechenov University, Moscow).

Author information

Authors and Affiliations

  1. Anokhin Research Institute of Normal Physiology, Moscow, Russia

    L. V. Mezentseva & E. V. Nikenina

  2. Sechenov First Moscow State Medical University, Moscow, Russia

    E. N. Dudnik & E. V. Nikenina

Authors
  1. L. V. Mezentseva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. N. Dudnik
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. V. Nikenina
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to L. V. Mezentseva.

Ethics declarations

COMPLIANCE WITH ETHICAL STANDARDS

All studies were carried out in accordance with the principles of biomedical ethics formulated in the Declaration of Helsinki of 1964 and its subsequent updates, and approved by the local bioethics committee of the Anokhin Research Institute of Normal Physiology (Moscow).

CONFLICT OF INTEREST

The authors declare no conflicts of interest.

INFORMED CONSENT

Each participant of the study provided voluntary written informed consent, signed after explanation of the potential risks and benefits, as well as the nature of the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mezentseva, L.V., Dudnik, E.N. & Nikenina, E.V. Comparative Analysis of Microcirculatory Reactions to Hypoxic Effects in Male and Female Subjects. Hum Physiol 48, 170–175 (2022). https://doi.org/10.1134/S0362119722020116

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0362119722020116

Keywords:

Search

Navigation