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Evaluation of Phosphorus–Calcium Homeostasis Parameters in Young People with Various Serum Levels of 25(OH)D Living in the Arctic Region

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Abstract

The parameters of phosphorus–calcium metabolism at different levels of 25 (OH)D in young people have been studied. The studied population included 48 young men and 126 young women aged 18 to 20 years. Normal values of vitamin D were found in 40 subjects (23%); the blood level of 25-OH vitamin D was shown to be 20–30 ng/mL in 59 subjects (34%), 10–19 ng/mL in 56 subjects (32%), and <10 ng/mL in 19 subjects (11%). The calcium level proved to be associated with the rate of vitamin D deficiency. The level of parathyroid hormone was not elevated in 75% of the subjects with vitamin D deficiency. There is no correlation between PTH levels and vitamin D levels. The results show the necessity of further studies to find out the causes of insufficient response of parathyroid hormone to vitamin D deficiency.

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REFERENCES

  1. DeLuca, H.F., Overview of general physiologic features and functions of vitamin D, Am. J. Clin. Nutr., 2004, vol. 80, no. 6, p. 1689S.

    Article  CAS  Google Scholar 

  2. Christakos, S., Ajibade, D.V., Dhawan, P., et al., Vitamin D: metabolism, Endocrinol. Metab. Clin. North Am., 2010, vol. 39, p. 243.

    Article  CAS  Google Scholar 

  3. Richter, B. and Faul, Ch., FGF23 actions on target tissues—with and without Klotho, Front. Endocrinol. (Lausanne), 2018, vol. 2, no. 9, p. 189.

    Article  Google Scholar 

  4. Holick, M.F., Vitamin D deficiency, N. Engl. J. Med., 2007, vol. 357, p. 266.

    Article  CAS  Google Scholar 

  5. Zhilyaev, E.V., Glazunov, A.V., Glazunov, P.A., et al., Disorders of vitamin D metabolism in clinical practice, Klin. Med., 2012, vol. 90, no. 7, p. 14.

    Google Scholar 

  6. Klimova, Zh.A., Zaft, A.A., and Zaft, V.B., Modern laboratory diagnostics of osteoporosis, Mezhdunar. Endokrinol. Zh., 2014, no. 7 (63), p. 75.

  7. Holick, M.F. The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention, Rev. Endocrinol. Metab. Disord., 2017, vol. 18, p. 153.

    Article  CAS  Google Scholar 

  8. Dedov, I.I., Mel’nichenko, G.A., Mokrysheva, N.G., et al., Primary hyperparathyroidism: the clinical picture, diagnostics, differential diagnostics, and methods of treatment, Probl. Endokrinol., 2016, vol. 62, no. 6, p. 40.

    Article  Google Scholar 

  9. Pascale, A.V., Finelli, R., Giannotti, R., et al., Vitamin D, parathyroid hormone and cardiovascular risk: the good, the bad and the ugly, J. Cardiovasc. Med. (Hagerstown), 2018, vol. 19, no. 2, p. 62.

    Article  CAS  Google Scholar 

  10. Sotunde, O.F., Kruger, H.S., Wright, H.H., et al., Association of 25-hydroxyvitamin D and parathyroid hormone with the metabolic syndrome in black South African women, Appl. Physiol. Nutr. Metab., 2017, vol. 42, no. 4, p. 413.

    Article  CAS  Google Scholar 

  11. Raposo, L., Martins, S., Ferreira, D., et al., Vitamin D, parathyroid hormone and metabolic syndrome—the PORMETS study, BMC Endocrinol. Disord., 2017, vol. 17, no. 1, p. 71.

    Article  Google Scholar 

  12. Ha, J., Jo, K., Lim, D.J., et al., Parathyroid hormone and vitamin D are associated with the risk of metabolic obesity in a middle-aged and older Korean population with preserved renal function: a cross-sectional study, PLoS One, 2017, vol. 12, no. 4, p. e0175132.

    Article  Google Scholar 

  13. Choi, S.W., Kweon, S.S., Lee, Y.H., et al., 25-hydroxyvitamin D and parathyroid hormone levels are independently associated with the hemoglobin A1c level of Korean type 2 diabetic patients: The Dong-Gu study, PLoS One, 2016, vol. 11, no. 6, p. e0158764.

    Article  Google Scholar 

  14. van Ballegooijen, A.J., Kestenbaum, B., Sachs, M.C., et al., Association of 25-hydroxyvitamin D and parathyroid hormone with incident hypertension: MESA (Multi-Ethnic Study of Atherosclerosis), J. Am. Coll. Cardiol., 2014, vol. 63, no. 12, p. 1214.

    Article  CAS  Google Scholar 

  15. Kilicarslan, A., Aslan, A.C., and Gezgen, G., The role of vitamin D deficiency in parathyroid hormone levels, Turk. J. Med. Sci., 2013, vol. 43, no. 3, p. 368.

    CAS  Google Scholar 

  16. Mahmood, S., Rahman, M., Biswas, S.K., et al., Vitamin D and parathyroid hormone status in female garment workers: a case-control study in Bangladesh, BioMed Res. Int., 2017, vol. 2017, art. ID 4105375. https://doi.org/10.1155/2017/4105375

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Serdar, M.A., Batu Can, B., Kilercik, M., et al., Analysis of changes in parathyroid hormone and 25 (OH) vitamin D levels with respect to age, gender and season: a data mining study, J. Med. Biochem., 2017, vol. 36, no. 1, p. 73.

    Article  CAS  Google Scholar 

  18. Durá-Travé, T. and Gallinas-Victoriano, F., Seasonal variations in calcidiol and parathyroid hormone levels in healthy children and adolescents in Navarre, Spain: a cross-sectional study, JRSM Open, 2016, vol. 7, no. 4, p. 2054270416632704.

    PubMed  PubMed Central  Google Scholar 

  19. Sai, A.J., Walters, R.W., Fang, X., and Gallagher, J.C., Relationship between vitamin D, parathyroid hormone, and bone health, J. Clin. Endocrinol. Metab., 2011, vol. 96, no. 3, p. E436.

    Article  CAS  Google Scholar 

  20. Shibli-Rahhal, A. and Paturi, B., Variations in parathyroid hormone concentration in patients with low 25 hydroxyvitamin D, Osteoporos Int., 2014, vol. 25, no. 7, p. 1931.

    Article  CAS  Google Scholar 

  21. Valcour, A., Blocki, F., Hawkins, D.M., and Rao, S.D., Effects of age and serum 25-OH-vitamin D on serum parathyroid hormone levels, J. Clin. Endocrinol. Metab., 2012, vol. 97, no. 11, p. 3989.

    Article  CAS  Google Scholar 

  22. Garg, M.K., Tandon, N., Marwaha, R.K., et al., The relationship between serum 25-hydroxy vitamin D, parathormone, and bone mineral density in Indian population, Clin. Endocrinol., 2014, vol. 80, p. 41.

    Article  CAS  Google Scholar 

  23. Sahota, O., Mundey, M.K., San, P., et al., The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis, Bone, 2004, vol. 35, no. 1, p. 312.

    Article  CAS  Google Scholar 

  24. Holick, M.F., Binkley, N.C., Bischoff-Ferrari, H.A., et al., Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline, J. Clin. Endocrinol. Metab., 2011, vol. 96, no. 7, p. 1911.

    Article  CAS  Google Scholar 

  25. Katrinaki, M., Kampa, M., Margioris, A., et al., Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values, Hormones (Athens), 2016, vol. 15, no. 2, p. 205.

    Article  Google Scholar 

  26. Chashchin, V.P., Gudkov, A.B., Popova, O.N., et al., Characteristics of the general risk factors for impairment of the health of the population living in areas of active nature management in the Arctic, Ekol. Chel., 2014, no. 1, p. 3.

  27. Kannan, S., Mahadevan, S., Velayutham, P., et al., Estimation of magnesium in patients with functional hypoparathyroidism, Indian J. Endocrinol. Metab., 2014, vol. 18, no. 6, p. 821.

    Article  Google Scholar 

  28. Sahota, O., Mundey, M.K., San, P., et al., Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency, Osteoporos Int., 2006, vol. 17, no. 7, p. 1013.

    Article  CAS  Google Scholar 

  29. Gunnarsson, O., Indridason, O.S., Franzson, L., et al., Factors associated with elevated or blunted PTH response in vitamin D insufficient adults, J. Int. Med., 2009, vol. 265, no. 4, p. 488.

    Article  CAS  Google Scholar 

  30. Paik, J.M., Farwell, W.R, and Taylor, E.N., Demographic, dietary, and serum factors and parathyroid hormone in the National Health and Nutrition Examination Survey, Osteoporos Int., 2012, vol. 23, no. 6, p. 1727.

    Article  CAS  Google Scholar 

  31. Sadat-Ali, M., Al-Omran, A.S., and Al-Turki, H.A., Parathyroid glands response to low vitamin D levels in healthy adults: a cross-sectional study, Ulster Med. J., 2015, vol. 84, no. 1, p. 26.

    PubMed  PubMed Central  Google Scholar 

  32. Jeong, S., Kim, I.W., Oh, K.H., et al., Pharmacogenetic analysis of cinacalcet response in secondary hyperparathyroidism patients, Drug Des. Dev. Ther., 2016, vol. 10, p. 2211.

    Article  CAS  Google Scholar 

  33. Hendy, N. and Canaff, L., Calcium-sensing receptor gene: regulation of expression Geoffrey, Front. Physiol., 2016, vol. 7, p. 394.

    Article  Google Scholar 

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ACKNOWLEDGMENTS

We are grateful to researchers of the Central Research Laboratory of the Northern State Medical University (Arkhangelsk).

Funding

The study was supported by the Northern State Medical University (Arkhangelsk).

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Authors and Affiliations

  1. Northern State Medical University, Ministry of Health of the Russian Federation, Arkhangelsk, Russia

    S. I. Malyavskaya, G. N. Kostrova, A. V. Strelkova & A. V. Lebedev

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  1. S. I. Malyavskaya
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  2. G. N. Kostrova
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  3. A. V. Strelkova
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  4. A. V. Lebedev
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Correspondence to G. N. Kostrova.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of the Northern State Medical University (Arkhangelsk), Protocol no. 04/01-16 of February 3, 2016, and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by E. V. Makeeva

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Malyavskaya, S.I., Kostrova, G.N., Strelkova, A.V. et al. Evaluation of Phosphorus–Calcium Homeostasis Parameters in Young People with Various Serum Levels of 25(OH)D Living in the Arctic Region. Hum Physiol 45, 679–684 (2019). https://doi.org/10.1134/S0362119719040108

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  • DOI: https://doi.org/10.1134/S0362119719040108

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