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Microstructural abnormalities of the corpus callosum and fasciculus uncinatus and auditory information processing in patients with juvenile paroxysmal schizophrenia

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Abstract

One approach to the problem of determining the mechanisms coupling the structure and functions of the brain is studies in clinical populations aimed at assessing the presence or absence of congruence of anatomical/ morphological and functional abnormalities. Magnetic resonance imaging (MRI), including structural MRI and diffusion tensor imaging with tractography, as well as the recording of auditory event-related potentials (ERPs) in the standard two-tone oddball paradigm and the sensory gating paradigm, was conducted in 26 male patients with paroxysmal juvenile schizophrenia and 26 mentally healthy men with no family history of mental illness. MRI abnormalities have been found in the genu of the corpus callosum and fasciculus uncinatus of the left hemisphere of the patients. Reduction of the fractional anisotropy in the genu of the corpus callosum was correlated with P300 reduction in the right temporal region.

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Authors and Affiliations

  1. Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, 115522, Russia

    I. S. Lebedeva, S. A. Karelin, A. S. Tomyshev, A. N. Barhatova & V. G. Kaleda

  2. Moscow State University, Moscow, 119992, Russia

    S. A. Karelin

  3. Research Institute for Children’s Emergency Surgery and Traumatology, Moscow Department of Healthcare, Moscow, 119180, Russia

    T. An. Ahadov, M. V. Ublinskiy & N. A. Semenova

  4. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119334, Russia

    N. A. Semenova

  5. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, 119991, Russia

    N. A. Semenova

Authors
  1. I. S. Lebedeva
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  2. S. A. Karelin
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  3. T. An. Ahadov
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  4. A. S. Tomyshev
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  5. M. V. Ublinskiy
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  6. N. A. Semenova
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  7. A. N. Barhatova
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  8. V. G. Kaleda
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Corresponding author

Correspondence to I. S. Lebedeva.

Additional information

Original Russian Text © I.S. Lebedeva, S.A. Karelin, T.An. Ahadov, A.S. Tomyshev, M.V. Ublinskiy, N.A. Semenova, A.N. Barhatova, V.G. Kaleda, 2016, published in Fiziologiya Cheloveka, 2016, Vol. 42, No. 4, pp. 27–31.

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Lebedeva, I.S., Karelin, S.A., Ahadov, T.A. et al. Microstructural abnormalities of the corpus callosum and fasciculus uncinatus and auditory information processing in patients with juvenile paroxysmal schizophrenia. Hum Physiol 42, 371–375 (2016). https://doi.org/10.1134/S0362119716040125

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  • DOI: https://doi.org/10.1134/S0362119716040125

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