Abstract
The dynamics of the glycemic curve profile was investigated in 8 healthy women during performance of the glucose tolerance test (GТТ) in 120-day antiorthostatic hypokinesia (–6°) (АNОH) simulating the effects of weightlessness. Glycemic profiles were characterized by more marked hyperglycemic response at 30 min of GТТ in the first month of stay under ANOH conditions and had a flattened appearance three months later. Glycemic profiles characteristic of delayed restoration of the blood glucose concentration appeared in the fourth month, which persisted over the first week after the end of АNОH. The glycemic profile changes developed against the background of the signs of progressive congestion of blood in the venous system of the abdominal cavity. The expansion of diameters of the main veins of the abdominal cavity was noted at the beginning of АNОH; an increase in the size of the organs and the signs of expansion of venous plexuses at the site of portocaval anastomoses, after three months; the occurrence of the signs of transudation and free fluid in the abdominal cavity was revealed at the end of hypokinesia. The countermeasures against hypodynamia did not prevent transformation of the glycemic profile nor did they influence the progression of blood flow congestion in the venous system of the abdominal cavity whose features determined the character changes in the glycemic profile in different periods of ANOH.
Similar content being viewed by others
References
Smirnov, K.V. and Ugolev, A.M., Kosmicheskaya gastroenterologiya (Space Gastroenterology), Moscow: Nauka, 1981.
Smirnov, K.V., Development of hypokinetic syndrome in the digestive system under microgravity, Fiziol. Zh. SSSR im. I. M. Sechenova, 1992, vol. 78, no. 8, p. 93.
Smirnov, K.V. and Ugolev, A.M., Digestion and Absorption Space Biology and Medicine, vol. 3: Humans Spaceflight, Moscow: Nauka, 1977.
Afonin, B.V., The effect of space flight and conditions of antiorthostatic hypokinesia of varying duration on the concentration of blood insulin, Kosm. Biol. Aviakosm. Med., 1989, vol. 23, no. 3, p. 77.
Stein, T., Schluter, M., and Boden, G., Development of insulin resistance by astronauts during spaceflight, Aviat., Space Environ. Med., 1994, vol. 65, no. 12, p. 1091.
Alexandrov, A., Gharib, C., Grigoriev, A.I., et al., Tests d`hyperglycemie provoquee par voie orale ches l`homme aucours d`un vol spatial de 150 jours, C.R. Soc. Biol., 1985, vol. 179, p. 192.
Afonin, B.V., The state of the digestive system under conditions of the long-term space flights and hypokinesia, Ross. Zh. Gastroenterol., Gepatol., Koloproktol., 1999, vol. 9, suppl. 7, p. 5.
Kamyshnikov, V.S., Kliniko-biokhimicheskaya laboratornaya diagnostika (Clinical and Biolchimical Laboratory Diagnostics), vol. 2: Glucose Tolerance Tests, Minsk, 2003.
Smirnov, K.V., Ruvinova, L.G., Afonin, B.V., et al., Functional test with a carbohydrate load under the 237- day spaceflight conditions, Kosm. Biol. Aviakosm. Med., 1999, vol. 25, no. 3, p. 6.
Afonin, B.V., Noskov, V.B., and Polyakov, V.V., The state of the digestive organs during long spaceflight, Hum. Physiol., 2003, vol. 29, no. 5, p. 561.
Afonin, B.V., Analysis of possible causes of activation of gastric and the pancreatic excretory and incretory function after completion of space flight at the international space station, Hum. Physiol., 2013, vol. 39, no. 5, p. 504.
Zvenigorodskaya, L.A., Konev, Yu.V., and Efremov, L.I., The evolution of ideas about the metabolic syndrome, Eksp. Klin. Gastroenterol., 2010, no. 7, p. 3.
Gardner, D. and Shobek, D., Bazisnaya i klinicheskaya endokrinologiya (Basic and Clinical Endocrinology), Moscow: Binom, 2010.
Smirnov, K.V., Pishchevarenie i gipokineziya (Digestion and Hypokinesia), Moscow: Meditsina, 1990.
Goland-Ruvinova, L.G., Pechenkina, R.A., Goncharova, N.P., and Smirnov, K.V., Functional test with a carbohydrate load under the conditions of continuous anti-orthostatic hypokinesia, Kosm. Biol. Aviakosm. Med., 1986, vol. 20, no. 6, p. 41.
Afonin, B.V., Nichiporuk, I.A., Nesterov, M.A., et al., Results of studies of carbohydrate metabolism and ultrasonography of the pancreas in man after continuous anti-orthostatic hypokinesia, Aviakosm. Ekol. Med., 1999, vol. 33, no. 4, p. 23.
Smirnov, K.V., Ruvinova, L.G., Medkova, I.L., et al., Functional status of the pancreas during prolonged bed rest, Fiziol. Chel., 1986, vol. 12, no. 3, p. 499.
Dergachev, A.I. and Kotlyarov, P.M., Abdominal’naya ekhografiya (Abdominal Echography), Moscow, 2003.
Glantz, S., Mediko-biologicheskaya statistika (Biomedical Statistics), Moscow: Praktika, 1998.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © B.V. Afonin, 2016, published in Fiziologiya Cheloveka, 2016, Vol. 42, No. 4, pp. 88–95.
Rights and permissions
About this article
Cite this article
Afonin, B.V. Dynamics of the glycemic profile in women in long-term antiorthostatic hypokinesia. Hum Physiol 42, 425–431 (2016). https://doi.org/10.1134/S0362119716040022
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0362119716040022