Abstract
The paper presents the results of investigating the lower limbs venous status in cosmonauts (n = 13) with the use of occlusion plethysmography in six-month missions to the Russian segment of International space station (ISS). An interrelation of shifts in venous capacitance, compliance and filling with orthostatic tolerance (OT) in the lower body negative pressure test (LBNP) was stated. OT predictability by the leg vein status in the course of space flight was demonstrated. The objective changes in veins predictive of OT reduction were identified. There are three levels of changes in venous capacitance, compliance and filling that prognosticate respective reductions LBNP tolerance and were attested in 91% of the in-flight LBNP testing.
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References
Gazenko, O.G., Man in space, Kosm. Biol., 1984, vol. 18, no. 1, p. 3.
Grigor’ev, A.I. and Egorov, A.D., Phenomenology and mechanisms of change of the basic functions of the body in weightlessness, Kosm. Biol. Aviakosm. Med., 1988, vol. 22, no. 12, p. 4.
Grigor’ev, A.I. and Egorov, A.D., Regulation of the human cardiovascular system in microgravity, Vestn. Ross. Akad. Med. Nauk, 2002, no. 6, p. 52.
Egorov, A.D., Mechanisms of reduction of orthostatic tolerance in conditions of long-term space flight, Aviakosm. Ekol. Med., 2001, vol. 35, no. 6, p. 3.
Noskov, V.B., Nichiporuk, I.A., and Grigor’v, A.I., Dynamics of liquid-saturated mediums and composition of body in conditions of long-term space flight (bioimpedance analysis), Aviakosm. Ekol. Med., 2007, vol. 41, no. 3, p. 3.
Pestov, I.D. and Geratevol’, Z., Microgravity, in Principles of space biology and medicine, Moscow, 1994, vol. 2, no. 1, p. 324.
Fomina, G.A. and Kotovskaya, A.R., Changes in human venous hemodynamics in long-term space flights, Aviakosm. Ekol. Med., 2005, vol. 39, no. 4, p. 25.
Fomina, G.A., Kotovskaya, A.R., Pochuev, V.I., and Zhernavkov, A.F., Izmeneniya gemodinamicheskikh mekhanizmov, obespechivayushchikh ortostaticheskuyu ustoichivost’ cheloveka v dlitel’nykh kosmicheskikh poletakh, Aviakosm. Ekol. Med., 2005, vol. 39, no. 6, p. 9.
Khayutin, V.M., Shenderov, S.M., Zakharov, A.G., and Rogoza, A.N., Orthostatic intolerance of blood circulation: role of detraining of resistance vessels, Kosm. Biol. Aviakosm. Med., 1984, vol. 18, p. 4.
Shik, L.L., Sergeeva, K.A., and Moiseev, V.A., Study of causes of orthostatic intolerance, Probl. Kosm. Biol., Moscow, 1975, vol. 31, p. 157.
Lane, L.D., Plath, G., et al., Effects of head-down tilt for 10 days on the compliance of the leg, Acta Physiol. Scand., 1992, vol. 144, p. 53.
Grandpierre, R., Colleu, M., Hauttement, J.L., and Lemaire, R., Interet et ovens d’etude de la circulation sanguine peripherique an apesanteur, in Chelovek v kosmose (Man in Space) (Proc. IV Int. Symposium on the Main Problems of Human Life in Space, Yerevan, October 1–6, 1971), Gazenko, O.G. and Byurstedt, Kh., Eds., Moscow, 1974.
Grigoriev, A.I., Kotovskaya, A.R., and Fomina, G.A., The human cardiovascular system during space flight, Acta Astronaut., 2011, vol. 68, p. 1495.
Tyberg, J.V. and Hamilton, V.R., Orthostatic hypotension and the role of changes in venous capacitance, Med. Sci. Sport Exerc., 1996, vol. 28, p. 29.
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Original Russian Text © A.R. Kotovskaya, G.A. Fomina, 2013, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2013, Vol. 47, No. 1, pp. 37–42.
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Kotovskaya, A.R., Fomina, G.A. Human venous hemodynamics in microgravity and prediction of orthostatic tolerance in flight. Hum Physiol 41, 699–703 (2015). https://doi.org/10.1134/S0362119715070063
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DOI: https://doi.org/10.1134/S0362119715070063