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Optimization of continuous microbiological synthesis processes with nonlinear microbial growth kinetics

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Abstract

A methodology for solving the optimization problem for a widespread microbiological synthesis process is considered, and a numerical solution of the problem is presented. The methodology developed is based on substrate and product inhibition kinetics. The optimization problem is solved using the target component productivity Q p as the optimality criterion. Three variants of optimization problem formulation are considered: optimization of substrate concentration in the feed stream at a fixed dilution rate; dilution rate optimization at a fixed substrate concentration in the feed, S f ; optimization with respect to two variables—S f and Q p . A specific feature of the solution is that it is necessary to check whether the optimal values obtained are usable in the practical implementation of the synthesis process. Numerical results of optimization are presented for the three variants of problem formulation.

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Authors and Affiliations

  1. Moscow State Academy of Veterinary Medicine and Biotechnology, ul. Akademika Skryabina 23, Moscow, 109472, Russia

    Yu. L. Gordeeva

  2. Mendeleev University of Chemical Technology of Russia, Miusskaya pl. 9, Moscow, 125047, Russia

    L. S. Gordeev

Authors
  1. Yu. L. Gordeeva
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  2. L. S. Gordeev
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Correspondence to L. S. Gordeev.

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Original Russian Text © Yu.L. Gordeeva, L.S. Gordeev, 2015, published in Teoreticheskie Osnovy Khimicheskoi Tekhnologii, 2015, Vol. 49, No. 6, pp. 651–658.

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Gordeeva, Y.L., Gordeev, L.S. Optimization of continuous microbiological synthesis processes with nonlinear microbial growth kinetics. Theor Found Chem Eng 49, 829–835 (2015). https://doi.org/10.1134/S0040579515060044

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