Abstract
A study is performed of the effect amphiphilic polymer Pluronic F127 has on the activity and photostability of photodithazine (PZ) in the photogeneration of singlet oxygen (1О2) in a model reaction of photo-oxidation of tryptophan in water upon excitation with light at λ = 400 and 660 nm at different light power densities. The highest photocatalytic activity and photostability of photodithazine in 1O2 generation are observed upon excitation with light at a wavelength of 400 nm, a medium radiation power density, and in the presence of Pluronic F127 in the reaction medium. The model reactions can be used to select the photosensitizers (PS) of the system (the presence of amphiphilic polymer and other systems added along with photosensitizers) and the modes of the low-energy photodynamic effects on substrates characteristic of each photosensitizer that are most favorable for therapy (i.e., that contribute to the initiation of regenerative and immune processes).
Similar content being viewed by others
REFERENCES
A. Juzeniene, K. P. Nielsen, and J. E. Moan, J. Environ. Pathol. Toxicol. Oncol. 25, 7 (2006).
S. B. Brown, E. A. Brown, and I. Walker, Lancet Oncol. 5, 497 (2004).
A. A. Krasnovsky, Jr., Biophysics 49, 289 (2004).
P. G. Jonson, D. A. Bellnier, and B. W. Henderson, Photochem. Photobiol. 57, 50 (1993).
B. W. Henderson and D. A. Bellnier, Ciba Found. Symp. 146, 112 (1989).
F. Wilkinson, W. P. Helman, and A. B. Ross, J. Phys. Chem. Ref. Data 24, 663 (1995).
J. S. McCaughan, Jr., Drugs Aging 15, 49 (1999).
K. Plaetzer, B. Krammer, J. Berlanda, F. Berr, et al., Lasers Med. Sci. 24, 259 (2009).
G. Canti, A. de Simone, and M. Korbelik, Photochem. Photobiol. Sci. 1, 79 (2002).
R. R. Allison and K. Moghissi, Clin. Endosc. 46, 24 (2013).
A. L. Akopov, N. V. Kazakov, A. A. Rusanov, and A. Karlson, Fotodin. Terap. Fotodiagn., No. 2, 9 (2015).
Optical Biomedical Diagnostics, Ed. by V. V. Tuchin (Fizmatlit, Moscow, 2007), Vols. 1, 2 [in Russian].
I. V. Krasnikov, V. E. Privalov, A. Yu. Seteikin, and A. E. Fotiadi, Vestn. SPbGU, Ser. 11, No. 4 (2013).
A. B. Solovieva, P. I. Tolstih, N. S. Melik-Nubarov, et al., Laser Phys., No. 5, 1068 (2010).
N. L. Oleinick, R. L. Morris, and I. Belichenko, Photochem. Photobiol. Sci., No. 1, 1 (2002).
X. Ding, Q. Xu, F. Liu, et al., Cancer Lett. 26, 43 (2004).
B. W. Henderson and J. M. Donovan, Cancer Res. 49, 6896 (1989).
B. W. Henderson, B. Owczarczak, J. Sweeney, and T. Gessner, Photochem. Photobiol. 56, 513 (1992).
M. L. Agarwal, M. E. Clay, E. J. Harvey, H. H. Evans, et al., Cancer Res. 51, 5993 (1991).
E. A. Machinskaya and V. I. Ivanova-Radkevich, Fotodin. Terap. Fotodiagn., No. 4, 19 (2013).
T. G. Rudenko, A. B. Shekhter, A. E. Guller, N. A. Aksenova, et al., Photochem. Photobiol. 90, 1413 (2014).
A. B. Solov’eva, N. N. Glagolev, N. A. Aksenova, A. S. Kur’yanova, A. F. Vanin, V. A. Timofeeva, and P. S. Timashev, Russ. J. Phys. Chem. A 93, 1834 (2019).
A. V. Belikov and A. V. Skripkin, Laser Biomedical Technologies, Part 1: The School-Book (SPbGU ITMO, St. Petersburg, 2008) [in Russian].
T. M. Zhientaev, N. S. Melik-Nubarov, E. A. Litmanovitch, N. A. Aksenova, et al., Polymer Sci., Ser. A 51, 502 (2009).
Funding
This work was performed as part of State Task no. 0082-2019-0012.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated by O. Zhukova
Rights and permissions
About this article
Cite this article
Kur’yanova, A.S., Solov’eva, A.B., Glagolev, N.N. et al. Effect of the Wavelength and Intensity of Excitation Light on the Efficiency of Photogeneration of Singlet Oxygen by Photodithazine in the Presence of Pluronic F127 in Model Processes of Photo-Oxidation. Russ. J. Phys. Chem. 95, 1222–1229 (2021). https://doi.org/10.1134/S0036024421060170
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0036024421060170