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RETRACTED ARTICLE: A New Mixed-Ligand Ni(II) Complex: Crystal Structure, Protective and Anti-Inflammatory Activities of its Nanoparticles on Acute Viral Myocarditis by Reducing the Release of Inflammatory Cytokines TNF-α and IL-1β

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This article was retracted on 01 April 2024

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Abstract

By means of the mixed-ligand strategy, a new Ni(II)-bearing coordination complex [Ni(pda)(bimb)(H2O)](H2O)1.5(1, bimb = 6,6′-bis(1H-benzo[d]imidazol-2-yl)-2,2′-bipyridine, H2pda = 4,4′-(pyridine-2,6-diyl)dibenzoic acid) is successfully obtained by the reaction of Ni(NO3)2·6H2O, bimb, and H2pda under hydrothermal reaction conditions. Furthermore, the nanoparticles of 1 (nano-1) with a size distribution of around 160 nm can be produced via a grinding method. In the section of biological research, we describe the anti-inflammatory activity of nano-1 on the acute viral myocarditis model. In the CVB3-induced acute viral myocarditis model, the treatment effect of nano-1 is evaluated by determining the mice survival rate and the CVB3 titer. The anti-inflammatory activity of nano-1 is determined by the ELISA assay of TNF-α and IL-1β levels in plasma.

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Funding

This work was supported by grants from Research Projects of Institutions of Higher Learning in Inner Mongolia (NJZY17195) and Inner Mongolia Natural Science Foundation (2017MS(LH)0824).

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Author notes

  1. W.-X. Huo and D.-S. Bai contributed equally to this work.

Authors and Affiliations

  1. Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, P. R. China

    W. -X. Huo, D. -S. Bai & M. Zhao

  2. First Clinical Medical of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P. R. China

    X. -T. Liu & M. Zhao

  3. Tongliao City Hospital, Tongliao, Inner Mongolia, P. R. China

    Z. -F. Zhang

Authors
  1. W. -X. Huo
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  2. D. -S. Bai
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  3. X. -T. Liu
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  4. Z. -F. Zhang
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  5. M. Zhao
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Corresponding author

Correspondence to M. Zhao.

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The authors declare that they have no conflict of interests.

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Text © The Author(s), 2020, published in Zhurnal Strukturnoi Khimii, 2020, Vol. 61, No. 6, pp. 1001–1007.

This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1134/S0022476624040206

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A New Mixed-Ligand Ni(II) Complex: Crystal Structure, Protective and Anti-Inflammatory Activities of its Nanoparticles on Acute Viral Myocarditis by Reducing the Release of Inflammatory Cytokines TNF-α and IL-1β

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Huo, W.X., Bai, D.S., Liu, X.T. et al. RETRACTED ARTICLE: A New Mixed-Ligand Ni(II) Complex: Crystal Structure, Protective and Anti-Inflammatory Activities of its Nanoparticles on Acute Viral Myocarditis by Reducing the Release of Inflammatory Cytokines TNF-α and IL-1β. J Struct Chem 61, 948–954 (2020). https://doi.org/10.1134/S0022476620060153

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  • DOI: https://doi.org/10.1134/S0022476620060153

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