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Synthesis, Crystal Structure, and Anticancer Activity of a In(III) Coordination Polymer Based on a Flexible 5-(4-Carboxybenzyl)Isophthalic Acid Ligand

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Abstract

In this study, a new In(III)-based coordination polymer [In(cpt)](DMF)(H2O) (1, DMF = N,N-dimethylformamide) is prepared using a newly designed ligand 5-(4-carboxybenzyl)isophthalic acid (H3cpt). Complex 1 is characterized by single crystal and powder X-ray diffraction and the thermogravimetric analysis. The structure of 1 involves one-dimensional chain-like units containing In(III), further combined with cpt3-ligands to obtain a 3D framework structure. The ultrasonic treatment method is used to produce nanoparticles of 1 (nano 1). MTT assay was carried out to explore the cytotoxicity of nano 1 on HMEC-1 hemangioendothelioma cells, and RT-PCR was utilized to assess activation of the PTEN/PI3K/Akt pathway.

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Funding

This work was supported by grants from the Academic Development Project of Binzhou city (2015ZC0307).

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Authors and Affiliations

  1. Department of Cardiac Surgery, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, Shandong, P. R. China

    D. -X. Liu

  2. Department of Orthopedics, Binzhou People’s Hospital, Binzhou, Shandong, P. R. China

    G. Chen

  3. College of Nursing, Binzhou Polytechnic, Binzhou, Shandong, P. R. China

    H. -L. Guo, D. -M. Chen & W. -X. Zhang

  4. Department of Cardiovascular Medicine, the Third Affiliated Hospital of Guangzhou University, Guangzhou, Guangdong, P. R. China

    S. -H. Li

Authors
  1. D. -X. Liu
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  2. G. Chen
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  3. H. -L. Guo
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  4. D. -M. Chen
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  5. S. -H. Li
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  6. W. -X. Zhang
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Corresponding author

Correspondence to W. -X. Zhang.

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The authors declare that they have no conflict of interests.

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Text © The Author(s), 2020, published in Zhurnal Strukturnoi Khimii, 2020, Vol. 61, No. 4, pp. 611–616.

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Liu, D.X., Chen, G., Guo, H.L. et al. Synthesis, Crystal Structure, and Anticancer Activity of a In(III) Coordination Polymer Based on a Flexible 5-(4-Carboxybenzyl)Isophthalic Acid Ligand. J Struct Chem 61, 581–586 (2020). https://doi.org/10.1134/S0022476620040113

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  • DOI: https://doi.org/10.1134/S0022476620040113

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