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Role of Neurotransmitters in the Functioning of Olfactory Sensory Neurons

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Abstract

The review article addresses the literature data, from which it follows that olfactory sensory neurons (OSN) combine the properties typical for olfactory receptor cells designed to perceive odors and the characteristics inherent in CNS neurons. This is due to the fact that the membrane of olfactory cilia contains not only olfactory (odorant) receptor proteins, but also receptors for such neurotransmitters as glutamate, dopamine, serotonin, adrenaline, and acetylcholine that play a neuroprotective and modulating role in the functioning of the olfactory analyzer’s receptor apparatus. Moreover, the expression and functionality of receptors for these neurotransmitters in OSN is of particular interest because they are implicated in the pathogenesis of diseases, such as schizophrenia, Parkinson’s disease, and other neuropsychiatric disorders.

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Funding

The writing of this review article was supported by the Program of fundamental scientific research at the state Academies for 2014–2020 (SP-14, section 63).

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    E. V. Bigdai & V. O. Samoilov

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  1. E. V. Bigdai
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  2. V. O. Samoilov
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Contributions

Conceptualization and data collection (V.O.S.); data collection, manuscript writing and editing (E.V.B.).

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Correspondence to E. V. Bigdai.

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The authors declare that they have neither evident nor potential conflict of interest related to the publication of this article.

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Translated by A. Polyanovsky

Russian Text © The Author(s), 2022, published in Rossiiskii Fiziologicheskii Zhurnal imeni I.M. Sechenova, 2022, Vol. 108, No. 6, pp. 699–711https://doi.org/10.31857/S0869813922060012.

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Bigdai, E.V., Samoilov, V.O. Role of Neurotransmitters in the Functioning of Olfactory Sensory Neurons. J Evol Biochem Phys 58, 865–874 (2022). https://doi.org/10.1134/S0022093022030206

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