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Role of LIM Kinase 1 in Dopaminergic and Serotonergic Neurons in Genome Stability, Learning and Memory during Stress Response to Weakening of Earth’s Magnetic Field in Drosophila

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Abstract

The paper continues the cycle of studies on the evolutionary link between the mechanisms of stress response formation and cognitive functions started in 1959 by M.E. Lobashev and V.B. Savvateev. We explore the role of a key neuroplasticity factor LIM kinase 1 (LIMK1) expressed in dopaminergic and serotonergic neurons in Drosophila genome stability, as well as learning and memory, both in standard conditions and when an organism exhibits a stress response to Earth’s weakened static magnetic field (WSMF). We demonstrate that a low LIMK1 level promotes learning acquisition, but not the formation of intermediate-term memory; at the same time, stress exposure restores the learning ability and memory formation in the Drosophila strain with an increased LIMK1 content. We identify inter-strain differences in the frequency of DNA double-strand breaks (DSBs) and show an increase in DSBs after the exposure to WSMF. The data obtained reveal the role of dopaminergic and serotonergic neurons not only in cognitive functions, but also as WSMF targets in the development of a stress response.

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Funding

This work was supported by the State Program RF 47 SP “Scientific and Technological Development of the Russian Federation” (2019–2030) (theme no. 63.1) and the Russian Foundation for Basic Research (RFBR) grant no. 20-015-00300A.

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    A. V. Medvedeva, A. V. Rebrova, E. S. Zalomaeva, E. A. Nikitina, E. V. Tokmacheva, S. A. Vasileva, B. F. Shchegolev & E. V. Savvateeva-Popova

  2. Herzen State Pedagogical University, St. Petersburg, Russia

    E. S. Zalomaeva, S. K. Turaeva, E. A. Nikitina & S. A. Vasileva

Authors
  1. A. V. Medvedeva
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  2. A. V. Rebrova
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  3. E. S. Zalomaeva
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  4. S. K. Turaeva
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  5. E. A. Nikitina
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  6. E. V. Tokmacheva
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  7. S. A. Vasileva
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  8. B. F. Shchegolev
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  9. E. V. Savvateeva-Popova
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Contributions

Basic idea and experimental design (E.A.N., A.V.M.); data processing, writing a manuscript (A.V.M.); problem posing, goal setting, selection of scientific literature (E.A.N.); behavioral experiments (E.S.Z., S.K.T.), S.A.V.); cytogenetic experiments (E.V.T., A.V.R.); preparing a manuscript (S.A.V.); data processing, experimental design (B.F.S.); supervision, writing a manuscript (E.V.S.-P.).

Corresponding author

Correspondence to E. V. Savvateeva-Popova.

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CONFLICT OF INTEREST

The authors declare that they have neither evident nor potential conflict of interest related to the publication of this article.

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Translated by A. Polyanovsky

Russian Text © The Author(s), 2022, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2022, Vol. 58, No. 1, pp. 34–42https://doi.org/10.31857/S0044452922010041.

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Medvedeva, A.V., Rebrova, A.V., Zalomaeva, E.S. et al. Role of LIM Kinase 1 in Dopaminergic and Serotonergic Neurons in Genome Stability, Learning and Memory during Stress Response to Weakening of Earth’s Magnetic Field in Drosophila. J Evol Biochem Phys 58, 35–44 (2022). https://doi.org/10.1134/S0022093022010033

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