Abstract
The rat strains Wistar, Wistar–Kyoto, Sprague Dawley, Long Evans, LT (low CNS excitability threshold), SHR, BD-IX (“Biocollection of the Pavlov Institute of Physiology”) were comparatively screened for the indicators of hormonal and antioxidant status as well as behavior. In male rats, the following characteristics were evaluated: behavioral (locomotor activity, anxiety level, depressive-like behavior in the Prosolt forced swim test), hormonal (corticosterone, dehydroepiandrosterone–DHEA, thyroid-stimulating hormone–TSH, thyroxine and testosterone levels) and blood antioxidative activity. Considering our data on physiological phenotyping the above rat strains, physiological maps were created for each strain and a specific descriptive biocollection format was elaborated to represent relevant information as a publicly available online resource (http://hst5.infran.ru/biocollection/) which can be helpful in choosing an experimental object and instrumental in analyzing data obtained on certain rat strains.
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Original Russian Text © E.A. Rybnikova, O.V. Vetrovoi, M.Yu. Zenko, 2018, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2018, Vol. 54, No. 5, pp. 331–338.
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Rybnikova, E.A., Vetrovoi, O.V. & Zenko, M.Y. Comparative Characterization of Rat Strains (Wistar, Wistar–Kyoto, Sprague Dawley, Long Evans, LT, SHR, BD-IX) by Their Behavior, Hormonal Level and Antioxidant Status. J Evol Biochem Phys 54, 374–382 (2018). https://doi.org/10.1134/S0022093018050058
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DOI: https://doi.org/10.1134/S0022093018050058