Abstract
The components of the antioxidant defense (AOD) system were analyzed in 74 male and female adolescents representing small ethnic groups that inhabit the territory of Eastern Siberia. Our findings indicate a dependence of the antioxidant status indicators on gender and ethnic identity of test subjects. More adaptive variants of the AOD system’s functioning were found in Tofalar boys (elevated levels of fat-soluble vitamins, increased glutathione system activity), whereas Evenk boys were characterized by a decreased activity of antioxidant factors (low α-tocopherol and retinol supply, glutathione system imbalance), as compared both to girls and Tofalar boys. The changes revealed in this group were also supported by increased values of the oxidative stress index.
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Kolesnikova, L.I., Darenskaya, M.A., Grebenkina, L.A., Labygina, A.V., Dolgikh, M.I., Natyaganova, L.V., and Pervushina, O.A., Problems of ethnos in medical studies, a review, Byull. VSNTs SO RAMN, 2013, vol. 92, no. 4, pp. 153–159.
Kolesnikova, L.I., Darenskaya, M.A., Grebenkina, L.A., Sholokhov, L.F., Semenova, N.V., Osipova, E.V., and Kolesnikov, S.I., Indicators of pituitary–thyroid system and lipid metabolism in female representatives of the Buryat ethnos and Europeoids, J. Evol. Biochem. Physiol., 2016, vol. 52, no. 4, pp. 299–304.
Agadzhanyan, N.A., Konovalova, G.M., and Ozheva, R.Sh., Ethnos, health and problems of adaptation, Nov. Tekhnol., 2010, no. 3, pp. 93–97.
Chanchaeva, E.A. and Aizman, R.I., Age-related changes in blood plasma antioxidant activity in population of the southern Altai, J. Evol. Biochem. Physiol., 2012, vol. 48, no. 2, pp. 152–154.
Kolesnikova, L.I., Darenskaya, M.A., Dolgikh, V.V., Shenin, V.A., Dutova, S.V., Grebenkina, L.A., and Dolgikh, M.I., Pro-and antioxidant status in Tofalar and Europeoid adolescents, Izv. Samar. Nauch. Ts. RAN, 2010, vol. 12, pp. 1687–1691.
Bichkaeva, F.A., Tretyakova, T.V., Vlasova, O.S., Gorelov, A.V., Loskutova, A.V., Godovykh, T.V., and Zhilina, L.P., Tocopherol and fatty acid blood levels in children and adolescents of the North, Ekol. Chel., 2010, no. 3, pp. 44–49.
Sokolova, T.V., Rychkova, M.P., Voinova, I.V., and Avrova, N.F., Dependence of protective effect of a-tocopherol on its concentration and time of action on pc12 cells under conditions of oxidative stress, J. Evol. Biochem. Physiol., 2011, vol. 47, no. 5, pp. 438–447.
Kolesnikova, L.I., Dolgikh, V.V., Bairova, T.A., and Bimbaev, A.B.Zh., Essentsialnaya arterialnaya gipertenziya i geny reninangiotenzin sistemy (Essential Arterial Hypertension and Genes of the Renin–Angiotensin System), Novosibirsk, 2008.
Kolesnikova, L.I., Grebenkina, L.A., Darenskaya, M.A., and Vlasov, B.Ya., Oxidative stress as a nonspecific pathogenetic link in reproductive disorders, a review, Sibir. Nauch. Med. Zh., 2012, vol. 32, no. 1, pp. 58–66.
Kolesnikova, L.I., Suturina, L.V., Labygina, A.V., Osipova, E.V., Leshchenko, O.Ya., Zagarskikh, E. Yu., Fedorov, B.A., Dolgikh, M.I., Sholokhov, L.F., Petrova, V.A., Nadelyaeva, Ya.G., Atalyan, A.V., Lazareva, L.M., Kornakova, N.V., and Darenskaya, M.A., The state of reproductive health, lipid peroxidation processes and antioxidant system in adolescents of the large industrial center Angarsk, Byull. VSNTs SO RAMN, 2005, no. 5, pp. 42–47.
Bregel, L.V., Gorodisky, B.V., Zabrodina, L.V., Kolokoltsev, M.M., Kolesnikova, L.I., Meriakri, V.S., Polyakov, V.M., Protopopova, N.V., Remarchuk, A.A., Starshinova, E.O., and Seliverstov, V.M., Sostoyanie zdorovya detskogo naseleniya Irkutskoi oblasti (Health State of Children’s Population of the Irkutsk Region), Irkutsk, 1991.
Kolesnikova, L.I., Dolgikh, V.V., Dzyatkovskaya, E.N., and Polyakov, V.M., Peculiarities of psycho-somatic status in preschool and school children, Sibir. Nauch. Med. Zh., 2003, vol. 23, no. 2, pp. 17–23.
Gavrilov, V.B. and Mishkorudnaya, N.I., Determination of DC in blood serum, Lab. Delo, 1983, no. 3, pp. 33–36.
Volchegorsky, I.A., Nalimov, A.G., Yarovinsky, B.G., et al., A comparison of different approaches to determination of lipid peroxidation products in heptane-isopropanol blood extracts, Vopr. Med. Khim., 1989, pp. 127–131.
Gavrilov, V.B., Gavrilova, A.R., and Mazhul, L.M., Analysis of methods of lipid peroxidation product determination in blood serum using the thiobarbituric acid test, Vopr. Med. Khim., 1987, no. 1, pp. 118–122.
Klebanov, G.I., Babenkova, I.V., Teselkin, Yu.O., Komarov, O.S., and Vladimirov, Yu.A., Evaluation of blood plasma antioxidant activity using bile lipoproteins, Lab. Delo, 1988, no. 5, pp. 59–62.
Chernyauskene, R.Ch., Varshkyavichene, Z.Z., and Gribauskas, P.S., Simultaneous determination of vitamin E and A concentrations in blood serum, Lab. Delo, 1984, no. 6, pp. 362–365.
Hisin, P.J. and Hilf, R., Fluorоmetric method for determination of oxidized and reduced glutathione in tissues, Anal. Biochem., 1976, vol. 74, pp. 214–226.
Misra, H.P. and Fridovich, I., The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase, J. Biol. Chem., 1972, vol. 247, pp. 3170–3175.
Rebrov, V.G. and Gromova, O.A., Vitaminy i mikroelementy (Vitamins and Microelements), Moscow, 2003.
Kolesnikova, L.I., Semenova, N.V., Grebenkina, L.A., Darenskaya, M.A., Suturina, L.V., and Gnusina, S.V., Integral indicator of oxidative stress evaluation in human blood, Byull. Eksper. Biol. Med., 2014, vol. 157, no. 6, pp. 680–683.
Ivanova, V.V., Govorova, L.V., Erbasskaya, A.V., and Alekseeva, L.A., Peculiarities of inflammatory response in children with high and low activity of free-radical oxidation in lymphocytes during the acute period of disease in different ethnic groups, Zh. Infektol., 2012, vol. 4, no. 3, pp. 46–52.
Kolesnikova, L.I., Dolgikh, V.V., Rychkova, L.V., Efimova, N.V., Pogodina, A.V., Mandzyak, T.V., and Polyakov, V.M., Peculiarities of health formation in children living in industrial centers, Sibir. Nauch. Med. Zh., 2008, vol. 28, vol. 4, pp. 72–76.
Kolesnikova, L.I., Dolgikh, V.V., Polyakov, V.M., Rychkova, L.V., Madaeva, I.M., Pogodina, A.V., and Protopopova, O.N., Psycho-physiological interrelationships under arterial hypertension during ontogenesis, Sibir. Nauch. Med. Zh., 2009, vol. 29, no. 5, pp. 79–85.
Kolesnikova,, L.I., Darenskaya, M.A., Grebenkina, L.A., Dolgikh, M.I., Astakhova, T.A., and Semenova, N.V., Gender differences in parameters of lipid metabolism and level of antioxidants in Evenk and Europeoid juvenile groups, J. Evol. Biochem. Physiol., 2014, vol. 50, no. 1, pp. 34–41.
Kolesnikova, L.I., Darenskaya, M.A., Grebenkina, L.A., Osipova, E.V., Dolgikh, M.I., and Natyaganova, L.V., The antioxidant status in children of different ages, Vopr. Pit., 2013, vol. 82, no. 4, pp. 27–33.
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Original Russian Text © L.I. Kolesnikova, M.A. Darenskaya, L.V. Rychkova, L.A. Grebenkina, N.V. Semenova, O.A. Gavrilova, 2018, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2018, Vol. 54, No. 2, pp. 116–121.
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Kolesnikova, L.I., Darenskaya, M.A., Rychkova, L.V. et al. Antioxidant Status in Adolescents of Small Siberian Ethnoses. J Evol Biochem Phys 54, 130–136 (2018). https://doi.org/10.1134/S0022093018020060
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DOI: https://doi.org/10.1134/S0022093018020060