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Functional role of membrane-bound adenylyl cyclases and coupled to them receptors and G-proteins in regulation of fertility of spermatozoa

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Abstract

The cAMP-dependent signaling cascades play the key role in regulation of fertility of spermatozoa. Synthesis of cAMP in spermatozoa is realized both by soluble, and by transmembrane (membrane-bound) forms of adenylyl cyclases (AC). For the recent years numerous data appeared about the presence in spermatozoa at different stages of their maturation of a wide spectrum isoforms of membrane-bound AC and their regulation by hormones and hormone-like substances via the coupled to B-proteins receptors (GPCR). Agonists of GPCR in spermatozoa can be adenosine, biogenic amines, peptide hormones, odorants. Study of structural-functional organization and regulatory properties of AC of the signal system in spermatozoa is of great practical significance for reproductive technologies, as via the membrane-bound AC forms and signal cascades there are controlled such processes as motility and chemotaxis of spermatozoa, their capability for capacitation acrosomal reaction. In the review there are summarized and analyzed data on functioning and role of AC of signal system in spermatozoa of human and vertebrate animals and are discussed achievements and unsolved problems in this field.

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Abbreviations

AdenR:

adenosine receptor

ACE:

angiotensin-converting enzyme

AP:

adrenergic receptor

AC:

adenylyl cyclase

ACSS:

adenylyl cyclase signaling system

GIDP:

5′-guanosine imidodiphosphate

GTPγS:

guanosine-5′-O-thiotriphosphate

PT:

pertussis toxin

MR:

melatonin receptor

sAC:

soluble adenylyl cyclase

SR:

serotonin receptor

tmAC:

transmembrane (membrane-bound) adenylyl cyclase

CT:

cholera toxin

FPP:

fertilization promoting peptide

GPCR:

G protein-coupled receptor)

MRP4:

multidrug resistance associated protein 4

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  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    A. O. Shpakov & K. V. Derkach

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Original Russian Text © A.O. Shpakov, K.V. Derkach, 2014, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2014, Vol. 50, No. 4, pp. 255–268.

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Shpakov, A.O., Derkach, K.V. Functional role of membrane-bound adenylyl cyclases and coupled to them receptors and G-proteins in regulation of fertility of spermatozoa. J Evol Biochem Phys 50, 286–302 (2014). https://doi.org/10.1134/S0022093014040024

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