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Changes in the Activity of Genes Involved in the Regulation of Hematopoiesis during Tumorigenesis in Irradiated Mice

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Abstract

We used 183 F1 CBA×C57Bl hybrid mice to study the delayed effects of low-power long-term γ-irradiation at a dose of 12.6 Gy (10 mGy/min) 8 and 10 months after the treatment. Eight months after the treatment we found the increased expression of the transcription factor NFκB and its target genes iNOS and G-SCF in the bone marrow (BM). Ten months after the treatment malignant lymphomas were revealed in 14 of 94 mice in the liver, abdominal cavity, and subcutaneously. In the BM of these mice, the transcription of the PTEN, NFκB, and iNOS genes was inhibited and the contents of long non-coding RNAs (lncRNAs) lnc p21, NEAT1, and microRNA miR-125b were decreased. The expression of the NFκB(p65) gene and miR-125b was inhibited in the BM of irradiated mice without tumors ten months after the treatment. These data show the deregulation of the P53 system supporting the genome stability in the BM of irradiated mice. These indices will be studied as potential markers of risk of development of irradiation-induced tumors.

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Funding

This study was supported by the Program of Development of Nuclear Medicine of AO Nauka i Innovatsii, State Corporation Rosatom.

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Authors and Affiliations

  1. Burnazyan Federal Medical Biophysical Center, Federal Biomedical Agency of the Russian Federation, 123098, Moscow, Russia

    D. V. Saleeva, V. F. Mikhailov, L. M. Rozhdestvenskii, L. V. Shulenina, N. F. Raeva & G. D. Zasukhina

  2. Vavilov Institute of General Genetics, Russian Academy of Sciences, 117971, Moscow, Russia

    G. D. Zasukhina

Authors
  1. D. V. Saleeva
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  2. V. F. Mikhailov
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  3. L. M. Rozhdestvenskii
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  4. L. V. Shulenina
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  5. N. F. Raeva
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  6. G. D. Zasukhina
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Corresponding author

Correspondence to D. V. Saleeva.

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Conflict of interest. The authors declare no conflict of interest.

Statement of the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by M. Stepanichev

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Saleeva, D.V., Mikhailov, V.F., Rozhdestvenskii, L.M. et al. Changes in the Activity of Genes Involved in the Regulation of Hematopoiesis during Tumorigenesis in Irradiated Mice. Dokl Biol Sci 491, 57–59 (2020). https://doi.org/10.1134/S0012496620020106

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  • DOI: https://doi.org/10.1134/S0012496620020106

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