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Changes in the Regulatory T-Lymphocyte Counts in HIV-Infected Patients with a Discordant Response to Antiretroviral Therapy

  • CELL BIOLOGY
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Abstract

We examined HIV-infected patients with different efficacies of immune system restoration during antiretroviral therapy. The study showed that against the background of low CD4+ T cell counts, subjects with a discordant immunologic response (patients with <350 CD4+ T cells per μL of blood after more than two years of treatment) develop a regulatory CD4+ T cell (Treg) deficiency. Furthermore, in these patients, the immunodeficiency is accompanied by an increase in the Treg frequency. Accumulation of regulatory T lymphocytes in the blood of HIV‑infected subjects with discordant response to the treatment indicates a high viability of this T cell subset.

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REFERENCES

  1. Battegay, M., Nuesch, R., Hirschel, B., and Kaufmann, G.R., Lancet Inf. Dis., 2006, vol. 6, pp. 280–287.

    Article  CAS  Google Scholar 

  2. Baker, J.V., Peng, G., Rapkin, J., et al., AIDS, 2008, vol. 22, pp. 841–848.

    Article  Google Scholar 

  3. Lapadula, G., Cozzi-Lepri, A., Marchetti, G., et al., AIDS, 2013, vol. 27, pp. 769–779.

    Article  CAS  Google Scholar 

  4. Piconi, S., Trabattoni, D., Gori, A., et al., AIDS, 2010, vol. 24, pp. 1991–2000.

    Article  CAS  Google Scholar 

  5. Marchetti, G., Gori, A., Casabianca, A., et al., AIDS, 2006, vol. 20, pp. 1727–1736.

    Article  Google Scholar 

  6. Hunt, P.W., Martin, J.N., Sinclair, E., et al., J. Inf. Dis., 2003, vol. 187, pp. 1534–1543.

    Article  CAS  Google Scholar 

  7. Sakaguchi, S., Annu. Rev. Immunol., 2004, vol. 22, pp. 531–562.

    Article  CAS  Google Scholar 

  8. Eggena, M.P., Barugahare, B., Jones, N., et al., J. Immunol., 2005, vol. 174, pp. 4407–4414.

    Article  CAS  Google Scholar 

  9. Moreno-Fernandez, M.E., Zapata, W., Blackard, J.T., Franchini, G., and Chougnet, C.A., J. Virol., 2009, vol. 83, pp. 12925–12933.

    Article  CAS  Google Scholar 

  10. Oswald-Richter, K., Grill, S.M., Shariat, N., et al., PLoS Biol., 2004, vol. 2, E198.

    Article  Google Scholar 

  11. Presicce, P., Orsborn, K., King, E., et al., PLoS One, 2011, vol. 6, e28118.

    Article  CAS  Google Scholar 

  12. Nobrega, C., Horta, A., Coutinho-Teixeira, V., et al., AIDS, 2016, vol. 30, pp. 1175–1186.

    Article  CAS  Google Scholar 

Download references

Funding

This work was supported by the Russian Foundation for Basic Research, project no. 17-54-30006.

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Authors and Affiliations

  1. Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, Russia

    E. V. Saidakova, K. V. Shmagel, N. G. Shmagel, L. B. Korolevskaya &  V. A. Chereshnev

  2. Institute of Immunology and Physiology of the Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia

    V. A. Chereshnev

Authors
  1. E. V. Saidakova
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  2. K. V. Shmagel
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  3. N. G. Shmagel
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  4. L. B. Korolevskaya
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  5. V. A. Chereshnev
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Corresponding author

Correspondence to E. V. Saidakova.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. The work plan was approved by the ethical Committee of the Perm regional center for protection against AIDS and infectious diseases (Reg. Committee no. IRB00008964). Written informed consent was obtained from each participant.

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Translated by I. Shipounova

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Saidakova, E.V., Shmagel, K.V., Shmagel, N.G. et al. Changes in the Regulatory T-Lymphocyte Counts in HIV-Infected Patients with a Discordant Response to Antiretroviral Therapy. Dokl Biol Sci 487, 128–131 (2019). https://doi.org/10.1134/S0012496619040082

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  • DOI: https://doi.org/10.1134/S0012496619040082

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