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Study of Uridine Effect on the Development of Audiogenic Tonic Seizures in Krushinsky–Molodkina Strain Rats

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Abstract

The latency of tonic seizure in response to loud sound (in rats of the Krushinsky–Molodkina strain with audiogenic epilepsy) had been slightly (although statistically significantly) longer after chronic uridine injections (100 mg/kg, i.p., three times a day during 9 or 12 days). The recovery time from the tonic seizure was shorter after 12 days of injections in comparison to the 9-day injection period. At the same time, the intensity of tonic seizures provoked by loud sound did not change after chronic uridine injections. The lack of uridine anticonvulsive effect demonstrated in the audiogenic epilepsy model contradicts the anticonvulsant effects of uridine in experiments with other seizure models, in which the epileptic foci were localized in the forebrain structures.

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Authors and Affiliations

  1. Biology Department, Moscow State University, Moscow, 119234, Russia

    I. B. Fedotova, G. M. Nikolaev, O. V. Perepelkina & I. I. Poletaeva

  2. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Poushchino, Moscow oblast, 142290, Russia

    N. V. Belosludtseva & G. D. Mironova

Authors
  1. I. B. Fedotova
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  2. G. M. Nikolaev
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  3. O. V. Perepelkina
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  4. N. V. Belosludtseva
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  5. G. D. Mironova
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  6. I. I. Poletaeva
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Corresponding author

Correspondence to I. I. Poletaeva.

Additional information

Original Russian Text © I.B. Fedotova, G.M. Nikolaev, O.V. Perepelkina, N.V. Belosludtseva, G.D. Mironova, I.I. Poletaeva, 2018, published in Doklady Akademii Nauk, 2018, Vol. 481, No. 1.

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Fedotova, I.B., Nikolaev, G.M., Perepelkina, O.V. et al. Study of Uridine Effect on the Development of Audiogenic Tonic Seizures in Krushinsky–Molodkina Strain Rats. Dokl Biol Sci 481, 125–127 (2018). https://doi.org/10.1134/S0012496618040014

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  • DOI: https://doi.org/10.1134/S0012496618040014

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