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Low-molecular-weight components of the metabolome control the proliferative activity in cellular and bacterial cultures

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Abstract

The effects of blood metabolites and model cell culture exometabolites found in the human and animal blood metabolomes have been assessed. Specifically, the influence of carboxylic acids that are structural analogues of amino acids and the drug Aktoflor-C have been studied. Methods of organotypic culturing of rat tissues and Escherichia coli bacterial culturing have been used. It has been found that all the tested compounds either stimulate or inhibit cell proliferation in tissue cultures and proliferation in bacterial cultures. The metabolites that are present in blood and interstitial fluids can exert regulation effects on the tissues of the body and intestinal microbiota.

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Authors and Affiliations

  1. National Research Institute of Highly Pure Biological Preparations, Russian Federal Biomedical Agency, St. Petersburg, 197110, Russia

    T. Ya. Vakhitov, E. V. Demyanova, A. S. Morugina & A. V. Petrov

  2. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    N. I. Chalisova, S. I. Sitkin, T. S. Sall, O. N. Shalaeva & A. D. Nozdrachev

  3. St. Petersburg State University, St. Petersburg, Russia

    A. F. Vinogradova & A. D. Nozdrachev

Authors
  1. T. Ya. Vakhitov
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  2. N. I. Chalisova
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  3. S. I. Sitkin
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  4. T. S. Sall
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  5. O. N. Shalaeva
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  6. E. V. Demyanova
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  7. A. S. Morugina
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  8. A. F. Vinogradova
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  9. A. V. Petrov
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  10. A. D. Nozdrachev
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Corresponding author

Correspondence to N. I. Chalisova.

Additional information

Original Russian Text © T.Ya. Vakhitov, N.I. Chalisova, S.I. Sitkin, T.S. Sall, O.N. Shalaeva, E.V. Demyanova, A.S. Morugina, A.F. Vinogradova, A.V. Petrov, A.D. Nozdrachev, 2017, published in Doklady Akademii Nauk, 2017, Vol. 472, No. 4, pp. 491–493.

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Vakhitov, T.Y., Chalisova, N.I., Sitkin, S.I. et al. Low-molecular-weight components of the metabolome control the proliferative activity in cellular and bacterial cultures. Dokl Biol Sci 472, 8–10 (2017). https://doi.org/10.1134/S0012496617010069

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  • DOI: https://doi.org/10.1134/S0012496617010069

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