Abstract
Cytokine production was evaluated in supernatants of cultured tumor cells that were obtained by biopsy of the breast invasive ductal carcinoma (IDC) and breast fibroadenoma (FA) and grown in vitro. In the IDC supernatants, the concentrations of pro-inflammatory (pro-oncogenic) cytokines IL-17, IL-18, and IFNγ and of IL-1 receptor antagonist were significantly higher than in the FA cell supernatants. The concentrations of anti-inflammatory cytokine IL-10 and MCP-1 protein in supernatants of IDC cells were significantly lower than those determined in FA supernatants.
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Mnikhovich, M.V., Vestn. Nov. Med. Tekhnol., 2013, no. 1.
Ben-Baruch, A., Breast Cancer Res., 2003, vol. 5, pp. 31–36.
Jain, R.K., Fukumura, D., and Duda, D.G., Cancer J., 2015, vol. 21, no. 4, pp. 235–236.
Lauder, I., Aherne, W., Stewart, J., and Sainsbury, R., J. Clin. Path., 1977, vol. 30, pp. 563–568.
Man, Y., Stojadinovic, A., Mason, J., Avital, I., Bilchik, A., Bruecher, B., Protic, M., Nissan, A., Izadjoo, M., Zhang, X., and Jewett, A., J. Cancer, 2013, vol. 4, no. 1, pp. 84–95.
Thomson, A.N. and Lotze, M.T., The Cytokine Handbook, San Diego Academic, 2003.
Triozzi, P.L., Aldrich, W., and Singh, A., Invest. Ophthalmol. Vis. Sci., 2011, vol. 52, no. 8, pp. 5529–5535.
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Original Russian Text © A.I. Autenshlyus, T.A. Kunts, K.V. Karpukhina, E.S. Mikhaylova, N.A. Varaksin, I.O. Marinkin, V.V. Lyakhovich, 2016, published in Doklady Akademii Nauk, 2016, Vol. 470, No. 2, pp. 237–238.
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Autenshlyus, A.I., Kunts, T.A., Karpukhina, K.V. et al. Cytokine pattern of the breast tumor supernatant. Dokl Biol Sci 470, 247–248 (2016). https://doi.org/10.1134/S0012496616050057
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DOI: https://doi.org/10.1134/S0012496616050057